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Chronic reduction of cholinesterase and the extinction of an operant response

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Summary

The extinction of an operant response was studied in rats in which cholinesterase activity was chronically inhibited to 30% of normal values. Resistance to extinction was related to the duration that cholinesterase had been reduced. The total number of extinction responses was less than for controls after 0 and 9 days and more after 18 and 36 days of reduced cholinesterase.

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Author notes

  1. A. J. Richardson

    Present address: Department of Psychology, University of New England, Armidale, N. S. W.

Authors and Affiliations

  1. Department of Psychology, The University of Adelaide, Australia

    P. H. Glow & A. J. Richardson

Authors
  1. P. H. Glow
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  2. A. J. Richardson
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Additional information

This investigation was supported by U. S. Public Health Service Grant NB 04427 from the National Institute of Neurological Diseases and Blindness.

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Glow, P.H., Richardson, A.J. Chronic reduction of cholinesterase and the extinction of an operant response. Psychopharmacologia 11, 430–434 (1967). https://doi.org/10.1007/BF00405027

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  • DOI: https://doi.org/10.1007/BF00405027

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