Summary
Serum creatine phosphokinase (CPK) and aldolase activities were determined in thirty-six subjects following the administration of LSD-25 or N,N-dipropyltryptamine in varying doses. No significant increase in the mean activity of either enzyme was found at the times blood samples were obtained after drug administration. The results are discussed with reference to the increases in CPK and aldolase activity which occur in the acute psychoses.
References
Berger, L.: Reagents for the aldolase assay were obtained from Calbiochem in the form of already-weighed mixtures. (unpublished).
Cao, A., DeVirgilis, S., Lippi, C., Trabalaz, N.: Creatine kinase isoenzymes in serum of children with neurological disorders. Clin chim. Acta 23, 475–478 (1969).
Dubo, H., Park, D. C., Pennington, R. J. T., Kalbag, R. M., Walton, J. N.: Serum creatine-kinase in case of stroke, head injury and meningitis. Lancet 1967 II, 743–748.
Kurland, A., Unger, S., Shaffer, J., Savage, C.: Psychedelic therapy utilizing LSD in the treatment of the alcoholic patient: A preliminary report. Amer. J. Psychiat. 123, 1202–1209 (1967).
Meltzer, H.: Creatine kinase and aldolase in serum: Abnormality common to acute psychoses. Science 159, 1368–1370 (1968).
Meltzer, H.: Technical comment. Science 164, 725–726 (1969a).
—: Muscle enzyme release in the acute psychoses. Arch. gen. Psychiat. 21, 102–112 (1969b).
— Increased activity of creatine phosphokinase and aldolase activity in the acute psychoses: Case Reports submitted to J. psychiat. Res. (1969c).
— unpublished observations (1969d).
Elkun, L., Moline, R.: Serum CPK activity in newly admitted psychiatric patients. I. Arch. gen. Psychiat. (in press) (1969a).
Grinspoon, L., Shader, R.: Serum CPK and Aldolase activity in acute schizophrenia, presented at the American Psychiatric Association, May 7, 1969, Miami Beach, Fla., 1969b.
Rosalki, S. B.: An improved procedure for serum creatine phosphokinase determination, J. Lab. clin. Med. 69, 696–705 (1967). Reagents were obtained from Calbiochem. in the form of already-weighed mixtures.
Warnock, D. G., Ellman, G. L.: Intramuscular chlorpromazine and creatine kinase: Acute psychoses or local muscle trauma? Science 164, 724 (1969).
Author information
Authors and Affiliations
Additional information
Supported in part by Grant # 14-340 from the State of Illinois and U.S.P.H.S. Grant # 1-R01-MH-16127-01.
Rights and permissions
About this article
Cite this article
Meltzer, H., Pahnke, W., Kurland, A. et al. Serum CPK and aldolase activity in man following controlled administration of psychotomimetic drugs. Psychopharmacologia 16, 419–425 (1970). https://doi.org/10.1007/BF00404853
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00404853