Skip to main content
SpringerLink
Log in

The biosynthesis of bacterial ribosomes and its regulation

  • Published:
Naturwissenschaften Aims and scope Submit manuscript

Abstract

Ribosome production consumes a substantial part of the energy of a bacterial cell. Exact regulation of the total number of ribosomes and accurate balancing of the amounts of ribosomal components are therefore of prime importance. In this article several regulatory mechanisms are reviewed and a novel model for the growth-dependent overall regulation of ribosome biosynthesis is proposed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gausing, K., in: Ribosomes: Structure, Function, and Genetics, p. 693 (eds. G. Chambliss et al). Baltimore: University Park Press 1980

    Google Scholar 

  2. Wittmann, H.G.: Ann. Rev. Biochem. 51, 155 (1982)

    Google Scholar 

  3. Young, R.A., Steitz, J.A.: Proc. Nat. Acad. Sci. USA 75, 3593 (1978)

    Google Scholar 

  4. Nomura, M., Morgan, E.A., Jaskunas, S.R.: Ann. Rev. Genet. 11, 297 (1977)

    Google Scholar 

  5. Traub, P., Nomura, M.: Proc. Nat. Acad. Sci. USA 59, 777 (1968)

    Google Scholar 

  6. Nierhaus, K.H., Dohme, F.: ibid. 71, 4713 (1974)

    Google Scholar 

  7. Mizushima, S., Nomura, M.: Nature 226, 1214 (1970)

    Google Scholar 

  8. Röhl, R., Nierhaus, K.H.: Proc. Nat. Acad. Sci. USA 79, 729 (1982)

    Google Scholar 

  9. Lindahl, L.: J. Mol. Biol. 92, 15 (1975)

    Google Scholar 

  10. Mangiarotti, G., et al: Biochemistry 7, 456 (1968)

    Google Scholar 

  11. Zimmermann, R.A., et al: Proc. Nat. Acad. Sci. USA 69, 1282 (1972)

    Google Scholar 

  12. Spillmann, S., Dohme, F., Nierhaus, K.H.: J. Mol. Biol. 115, 513 (1977)

    Google Scholar 

  13. Röhl, R., Roth, H.E., Nierhaus, K.H.: Hoppe-Seyler's Z. Physiol. Chem. 363, 143 (1982)

    Google Scholar 

  14. Gallant, J.A.: Ann. Rev. Genet. 13, 393 (1979)

    Google Scholar 

  15. Travers, A.A.: J. Mol. Biol. 141, 91 (1980)

    Google Scholar 

  16. Debenham, P.G., Pongs, O., Travers, A.A.: Proc. Nat. Acad. Sci. USA 77, 870 (1980)

    Google Scholar 

  17. Travers, A.A., Debenham, P.G., Pongs, O.: Biochemistry 19, 1651 (1980)

    Google Scholar 

  18. Travers, A.A.: Nature 244, 15 (1973)

    Google Scholar 

  19. Biebricher, C.K., Druminski, M.: Proc. Nat. Acad. Sci. USA 77, 866 (1980)

    Google Scholar 

  20. Young, R.A., Steitz, J.A.: Cell 17, 225 (1979)

    Google Scholar 

  21. Nomura, M., Dean, D., Yates, J.L.: Trends Biochem. Sci. 7, 92 (1982)

    Google Scholar 

  22. Nowotny, V., Nierhaus, K.H.: Proc. Nat. Acad. Sci. USA 79, 7238 (1982)

    Google Scholar 

  23. Jacob, F., Monod, J.: J. Mol. Biol. 3, 318 (1961)

    Google Scholar 

  24. Forchhammer, J., Kjeldgaard, N.O.: ibid. 37, 245 (1968)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Max-Planck-Institut für biophysikalische Chemie, D-3400, Göttingen

    Roland Röhl

Authors
  1. Roland Röhl
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

I am grateful to Dr. P. Woolley for critical reading of the manuscript.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Röhl, R. The biosynthesis of bacterial ribosomes and its regulation. Naturwissenschaften 70, 288–293 (1983). https://doi.org/10.1007/BF00404835

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00404835

Keywords

Search

Navigation