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Der Haupthistokompatibilitätskomplex und die Unterscheidung zwischen Selbst und Fremd durch das Immunsystem

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Abstract

The major histocompatibility complex (Mhc) is a cluster of closely linked genes which are involved in the distinction between self and non-self. The genes fall into two classes, I and II, which are evolutionarily related but specialized to performing somewhat different functions. The Mhc genes code for proteins which are seen together with foreign substances by the thymus-derived lymphocytes. These lymphocytes thus recognize simultaneously self (Mhc molecules) and non-self (foreign antigen). Some of the Mhc genes are highly polymorphic and this polymorphism probably represents a compensation for the fact that certain combinations of Mhc molecules and antigen fail to be recognized by the T lymphocyte.

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Authors and Affiliations

  1. Abteilung Immungenetik, Max-Planck-Institut für Biologie, D-7400, Tübingen

    Jan Klein, Hans -Georg Rammensee & Zoltan A. Nagy

Authors
  1. Jan Klein
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  2. Hans -Georg Rammensee
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  3. Zoltan A. Nagy
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Klein, J., Rammensee, H.G. & Nagy, Z.A. Der Haupthistokompatibilitätskomplex und die Unterscheidung zwischen Selbst und Fremd durch das Immunsystem. Naturwissenschaften 70, 265–271 (1983). https://doi.org/10.1007/BF00404832

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  • DOI: https://doi.org/10.1007/BF00404832

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