, Volume 9, Issue 2, pp 146–156 | Cite as

Effect of Psilocybin, LSD, and mescaline on small, involuntary eye movements

  • Frederick W. Hebbard
  • Roland Fischer
Original Investigations


The influence of Psilocybin, LSD, mescaline, or alcohol on physiological nystagmus was investigated. Eleven hundred eye-movement records served as control data. In 242 sessions, a significant, dose dependent increase in frequency and, to some extent, amplitude of saccades was found after the oral administration of 10–15 mg of Psilocybin, 120μg of LSD, or 450 mg of mescaline. These three drugs produced a characteristic square-wave pattern of saccades distinctively dissimilar from the saw-tooth pattern produced by alcohol. There was no difference between the control and placebo patterns. The recording of physiological nystagmus may provide a valuable biological parameter for studying the effects of various drugs.


Alcohol Placebo Oral Administration Dose Dependent Increase Control Data 
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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • Frederick W. Hebbard
    • 1
    • 2
  • Roland Fischer
    • 1
    • 2
  1. 1.School of OptometryThe Ohio State universityColumbusUSA
  2. 2.Department of PsychiatryThe Ohio State universityColumbusUSA

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