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Psychopharmacologia

, Volume 9, Issue 2, pp 146–156 | Cite as

Effect of Psilocybin, LSD, and mescaline on small, involuntary eye movements

  • Frederick W. Hebbard
  • Roland Fischer
Original Investigations

Summary

The influence of Psilocybin, LSD, mescaline, or alcohol on physiological nystagmus was investigated. Eleven hundred eye-movement records served as control data. In 242 sessions, a significant, dose dependent increase in frequency and, to some extent, amplitude of saccades was found after the oral administration of 10–15 mg of Psilocybin, 120μg of LSD, or 450 mg of mescaline. These three drugs produced a characteristic square-wave pattern of saccades distinctively dissimilar from the saw-tooth pattern produced by alcohol. There was no difference between the control and placebo patterns. The recording of physiological nystagmus may provide a valuable biological parameter for studying the effects of various drugs.

Keywords

Alcohol Placebo Oral Administration Dose Dependent Increase Control Data 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aschan, G., M. Bergstedt, L. Goldberg, and L. Laurell: Positional nystagmus in man during and after alcohol intoxication. Quart. J. Stud. Alcohol 17, 381 to 405 (1956).Google Scholar
  2. Ditchburn, R. W., and D. H. Fender: The stabilized retinal image. Optica Acta 2, 128–133 (1955).Google Scholar
  3. Dohlman, G.: Physikalische und physiologische Studien zur Theorie des kalorischen Nystagmus. Acta oto-laryng. (Stockh.), Suppl. No. 5 (1925).Google Scholar
  4. Fischer, R.: Sympathetic excitation and biological chronometry. Int. J. Neuropsychiat. (in press).Google Scholar
  5. —, S. M. England, R. C. Archer, and R. K. Dean: Psilocybin reactivity and time contraction as measured by psychomotor performance. Arzneimittel- Forsch. (Drug Res.) 16, 180–185 (1966).Google Scholar
  6. —, F. Griffin, R. C. Archer, S. C. Zinsmeister, and P. S. Jastram: The Weber ratio in gustatory chemoreception; an indicator of systemic (drug) reactivity. Nature (Lond.) 207, 1049–1053 (1965).Google Scholar
  7. -, and E. L. Mead: Psilocybin produced time contraction and psychomotor performance. Nature (Lond.) (in press).Google Scholar
  8. Hartline, H. K.: The response of single optic nerve fibers of the vertebrate eye to illumination of the retina. Amer. J. Physiol. 121, 400–415 (1938).Google Scholar
  9. Hebbard, F. W.: Eye Movements During Fixation and Fusion. Ph.D. Dissertation (University of California, Berkeley 1957).Google Scholar
  10. Hebbard, F. W.: Comparison of subjective and objective measurements of fixation disparity. J. Optical Soc. Amer. 52, 706–712 (1962).Google Scholar
  11. —, and E. Marg: Physiological nystagmus in the cat. J. Optical Soc. Amer. 50, 151–155 (1960).Google Scholar
  12. Hidalgo, W. T.: Estudio comparativo psicofisiológico de la Mesoalina, Dietilamida del ácido D-lisérgico y Psilocybina. Acta med. venez. 8, 56–62 (1960).Google Scholar
  13. Hofmann, A.: Chemical, pharmacological, and medical aspects of psychotomimetics. J. exp. med. Sci. 5, 32–51 (1961).Google Scholar
  14. —: Psychotomimetic substances. Indian J. Pharm. 25, 245–256 (1963).Google Scholar
  15. —, R. Heim, A. Brach, H. Kobel, A. Frey, H. Ott, T. Petrzilka, and F. Troxler: Psilocybin und Psilocin, zwei psychotrope Wirkstoffe aus mexikanischen Rauschpilzen. Helv. chim. Acta 42, 1557–1572 (1959).Google Scholar
  16. Isbell, H.: Comparison of the reactions induced by Psilocybin and LSD-25 in man. Psychopharmacologia (Berl.) 1, 29–38 (1959).Google Scholar
  17. —, A. B. Wolbach, A. Wilker, and E. J. Miner: Cross tolerance between LSD and Psilocyvin. Psychopharmacologia (Berl.) 2, 147–159 (1961).Google Scholar
  18. Rashbass, C.: The relationships between saccadic and smooth tracking eye movements. J. Physiol. (Lond.) 159, 326–338 (1961).Google Scholar
  19. Rauschke, J.: Alkohol-Nystagmus und Leistungsschädigung: experimentelle Untersuchungen zur Brauchbarkeit der Nystagmusprüfung beim Nachweis der Alkoholbeeinflussung. Medizinische 12, 460–465 (1958).PubMedGoogle Scholar
  20. Riggs, L. A., F. Ratliff, J. C. Cornsweet, and T. W. Cornsweet: The disappearance of steadily fixated visual test objects. J. Optical Soc. Amer. 43, 495–501 (1953).Google Scholar
  21. Rosenberg, D. E., A. B. Wolbach Jr., E. J. Miner, and H. Isbell: Observations on direct and cross tolerance with LSD and D-amphetamine in man. Psychopharmacologia (Berl.) 5, 1–15 (1963).Google Scholar
  22. Wolbach, A. B., Jr., H. Isbell, and E. J. Miner: Cross tolerance between mescaline and LSD-25. With a comparison of the mescaline and LSD reactions. Psychopharmacologia (Berl.) 3, 1–14 (1962).Google Scholar
  23. Young, L. R.: Measuring eye movements. Amer. J. med. Electron. 2, 300–307 (1963).Google Scholar

Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • Frederick W. Hebbard
    • 1
    • 2
  • Roland Fischer
    • 1
    • 2
  1. 1.School of OptometryThe Ohio State universityColumbusUSA
  2. 2.Department of PsychiatryThe Ohio State universityColumbusUSA

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