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The endogenous retrovirus Mtv-8 on mouse chromosome 6 maps near several kappa light chain markers

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Abstract

Endogenous retroviruses are known to affect expression of cellular genes in the vicinity of their integration sites. The endogenous mouse mammary tumor provirus (Mtv-8) previously has been reported to reside on mouse chromosome 6 near the immunoglobulin kappa chain locus. Using pairs of mouse strains on the BALB/c (Mtv-8 positive) and C58 (Mtv-8 negative) backgrounds which are congenic for chromosome 6 genetic markers, we have confirmed the chromosome assignment of this provirus. Moreover, we have analyzed the N1 progeny of a (B6 × C58) × C58 backcross to determine the segregation of the Mtv-8 provirus with respect to polymorphisms in the Igk-VSer and Igk-J loci. The results with congenic and backcross mice together with results of others suggest that Mtv-8 is located approximately 0.52 cM from several closely linked kappa markers on chromosome 6.

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Authors and Affiliations

  1. Department of Microbiology, University of Texas at Austin, 78712-1095, Austin, TX, USA

    Jsein-Ning Yang, R. Thomas Boyd, Paul D. Gottlieb & Jaquelin P. Dudley

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  1. Jsein-Ning Yang
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  2. R. Thomas Boyd
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  3. Paul D. Gottlieb
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  4. Jaquelin P. Dudley
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Yang, JN., Thomas Boyd, R., Gottlieb, P.D. et al. The endogenous retrovirus Mtv-8 on mouse chromosome 6 maps near several kappa light chain markers. Immunogenetics 25, 222–227 (1987). https://doi.org/10.1007/BF00404691

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  • DOI: https://doi.org/10.1007/BF00404691

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