Summary
The duration of the adrenocorticotrophic effects of two synthetic ACTH preparations was studied in healthy volunteers. One of the hormones, β 1–24 corticotropin, was adsorbed on zinc; the other, a D-serine1-norleucine4-valinamide25-β 1–25 corticotropin, was thought to be more stable, owing to the replacement of the three most susceptible amino acids in the ACTH molecule. —β 1–24 corticotropin, administered intramuscularly in a dose of 1 mg, showed biological activity lasting for 28 h, an effect equal to that which may be expected of depot preparations of pituitary extracts. D-serine1-norleucine4-valinamide25-β 1–25 corticotropin, administered intra muscularly in a dose of 0.16 mg, had only a weak adreno corticotrophic effect, whereas intravenously the same dose produced a greater effect that persisted for nearly 8 h. After intramuscular injection of both preparations a significant difference was found between the maximum responses shown by men and women.
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Haupt, E., Schemmel, K. & Leybold, K. Comparative invstigations on the duration of action of two synthetic corticotropins. Pharmacol. Clin. 1, 131–134 (1969). https://doi.org/10.1007/BF00404659
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DOI: https://doi.org/10.1007/BF00404659