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Studies on urinary excretion of the potassium-retaining diuretic amiloride (Desmethyl-pipazuroyl-guanidine, MK 870) in man

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Summary

1. A spectrophotofluorometric procedure is described by which the potassium-retaining diuretic amiloride is isolated from the urine by means of thin-layer chromatography. - 2. After administering single doses of 10 mg, the drug can be demonstrated in the urine up to 24 h, and after giving 20 mg, up to 48 h. The percentage recovered is independent of the dosage applied and is not influenced by diuresis, or by the concomitant administration of the saluretic, etacrynic acid. In patients with cirrhosis of the liver and portal hypertension the recovery of amiloride is identical to that of healthy controls. After fasting for four hours following the ingestion of the drug, the quantity of the diuretic excreted in the urine is approximately twice that after administration of amiloride at breakfast or shortly before.

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Authors and Affiliations

  1. I. Medizin. Klinik der Medizin, Akademie Kronsforder Allee 71/73, 24 Lübeck

    E. Schmid &  G. Fricke

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  1. E. Schmid
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  2. G. Fricke
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Schmid, E., Fricke, G. Studies on urinary excretion of the potassium-retaining diuretic amiloride (Desmethyl-pipazuroyl-guanidine, MK 870) in man. Pharmacol. Clin. 1, 110–113 (1969). https://doi.org/10.1007/BF00404655

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  • DOI: https://doi.org/10.1007/BF00404655

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