Summary
The experiment reported here examined the effects of central and autonomic stimulant and depressant drugs administered singly and in pairs on a form of exploratory behavior namely, rearing, in two strains of rats of both sexes. It was found that the central stimulant, amphetamine, increased rearing frequency and that the effect of this drug was diminished in combination with sodium amytal or methylpentynol. No sex or strain differences could be detected.
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References
Berlyne, D. E.: Conflict, arousal and curiosity. New York: McGraw Hill 1960.
Breggin, P. R.: Sedative-like effect of epinephrine. Arch. gen. Psychiat. 2, 255 to 259 (1965).
Cook, L., and A. C. Catania: Effects of drugs on avoidance and escape behavior. Fed. Proc. 23, 818–835 (1964).
Dicker, S. E., H. Steinberg, and R. H. J. Watson: The effect of methylpentynol on the activity of rats. J. Physiol (Lond.) 137, 88 (1957).
Goodman, L. S., and A. Gillman: The Pharmacological basis of therapeutics (2nd Ed.). New York: Macmillan 1955.
Gregory, K., B. D. Gupta and H. C. Holland: The effects of drugs on activity in two strains of rats selectively bred for high and low emotionality. Life Sci. 6, 981–988 (1967).
Gregory, K., and Elsa Liebelt: An examination of sex and strain differences in the rearing response to a novel environment. Activ. nerv. sup. (Praha) 9, 137–139 (1967).
Herz, L.: Drugs and the conditioned avoidance response. Int. Rev. Neurobiol. 2, 229–272 (1960).
Holland, H. C., and B. D. Gupta: The effects of different doses of methylpentynol on escape/avoidance conditioning in two strains selectively bred for high and low ‘emotionality’. Psychopharmacologia (Berl.) 9, 419–425 (1966).
- - Effects of drugs on the rearing response in emotionally reactive and nonreactive rats. (In Press) (1967).
— — and E. Weldon: A note on rearing and an environmental restraint. Activ. nerv. sup. (Praha) 8, 140–144 (1966).
Kosman, M. E., and R. W. Gerard: The effects of adrenaline on a conditioned avoidance response. 1955. J. comp. physiol. Psychol. 48, 506–508 (1955).
Lat, J.: Factors affecting the basic non-specific tonus of the central nervous system. In Gutman, A., and P. Hrik (Eds.): Central and peripheral mechanisms of the motor-functions. Proc. Conf. Czech. Acad. Sc., Prague, pp. 255–263 (1963).
—: The spontaneous exploratory reactions as a tool for psychopharmacological studies. A contribution towards a theory of contradictory results in psychopharmacology. In: Pharmacology of conditioning, learning and retention. Proc. 2nd Int. Pharmacol. Meeting. London: Pergamon 1965.
Magoun, H. W.: The waking brain. Springfield, Ill.: Ch. C. Thomas 1958.
Margolin, S.: Nonbarbiturates. In: Physiological pharmacology, Vol. 1, pp. 239 to 273. New York: Academic Press 1963.
Rushton, R., and H. Steinberg: Mutual potentiation of amphetamine and amylobarbitone measured by activity in rats. Brit. J. Pharmacol. 21, 295–305 (1963).
Singh, S. D., and H. J. Eysenck: A conditioned emotional response in the rat III drug antagonism. J. gen. Psychol. 63, 275–285 (1960).
Steinberg, H.: Drugs and animal behavior. Brit. med. Bull. 20, 75–80 (1964).
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Gupta, B.D., Gregory, K. The effects of drugs and their combinations on the rearing response in two strains of rats. Psychopharmacologia 11, 365–371 (1967). https://doi.org/10.1007/BF00404614
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DOI: https://doi.org/10.1007/BF00404614