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Autoradiographic and planimetric analyses of the inflammatory infiltrate in psoriatic lesions under PUVA-therapy

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Summary

The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA-therapy) on the inflammatory infiltrate in 14 psoriatic skinlesions and on normal skin of 7 controls were investigated by means of autoradiography and planimetry. Under PUVA-therapy, one finds a significant decrease in dermal cells per millimeter lesion in psoriasis. Percentage of 3H-TdR-labeled dermal cells in the lesions and total number of dermal cells in the control group do not change significantly. The relative decrease of dermal cells per millimeter lesion in psoriasis is far less significant than the reduction of 3H-TdR-labeled epidermal cells under PUVA-therapy.

Zusammenfassung

Mit Hilfe der Autoradiographie und Planimetrie wurde der Effekt der oralen 8-Methoxypsoralen-Photochemotherapie (PUVA-Therapie) auf das entzündliche Infiltrat in 14 Psoriasisläsionen im Vergleich zu Hautgesunden untersucht. Unter der PUVA-Therapie kommt es in psoriatischer Haut zu einem signifikanten Abfall der dermalen Zellen pro Millimeter Oberflächenlänge. Der prozentuale Anteil 3H-Thymidin-markierter dermaler Zellen in Psoriasisläsionen und die Gesamtzahl der dermalen Zellen in Kontrollhaut ändern sich nicht signifikant. Die relative Abnahme der dermalen Zellen pro Millimeter Oberflächenlänge ist wesentlich weniger ausgeprägt als der Rückgang der 3H-Thymidin-markierten epidermalen Zellen.

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Authors and Affiliations

  1. Dermatologische Klinik und Poliklinik der Universität München, Frauenlobstraße 9-11, D-8000, München 2, Germany

    Michael Landthaler, Gerd Plewig, Cornelia Hofmann & Otto Braun-Falco

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  1. Michael Landthaler
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  2. Gerd Plewig
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  3. Cornelia Hofmann
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  4. Otto Braun-Falco
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Additional information

Financial support was granted by the Deutsche Forschungsgemeinschaft (Grant No. Br 147/47 T1)

Lecture held at VIIth Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Innsbruck, Austria, November 16–18, 1979

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Landthaler, M., Plewig, G., Hofmann, C. et al. Autoradiographic and planimetric analyses of the inflammatory infiltrate in psoriatic lesions under PUVA-therapy. Arch Dermatol Res 269, 31–37 (1980). https://doi.org/10.1007/BF00404455

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  • DOI: https://doi.org/10.1007/BF00404455

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