Abstract
The polymorphic variation of liver GM1 (NeuGc) ganglioside was found in inbred strains of the mouse. The genetic analysis using C57BL/10 (GM1-negative) and SWR (GM1-positive) mice revealed that a single autosomal gene (Ggm-1) was involved in the expression of liver GM1(NeuGc) and that C57BL/10 mice lacking GM1(NeuGc) expression carried a defective gene on Ggm-1. Since our previous study on H-2 congenic mice indicated that Ggm-1 was linked to the H-2 complex, in this study we measured recombination frequencies among Ggm-1, Go-1 and H-2K in the backcross progeny between (C57BL/10 × SWR)F1 and C57BL/10. Ggm-1 was mapped 1 cM centromeric to H-2K on chromosome 17.
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Abbreviations
- GM1(NeuGc):
-
Galβ1-3GalNAcβ1-4 (NeuGcα2-3)Galβ1-4Glcβ1-ceramide
- GM2(NeuGc):
-
Galβ1-4(Neu Gcα2-3)Galβ1-4Glcβ1-ceramide
- GM3(NeuGc):
-
NeuGcα2-3Galβ1-4 Glcβ1-ceramide
- GD1a(NeuGc):
-
NeuGcα2-3Galβ1-3GalNAcβ1-4 (NeuGcα2-3)Galβ1-4Glcβ1-ceramide
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Sakaizumi, M., Hashimoto, Y., Suzuki, A. et al. The locus controlling liver GM1(NeuGc) expression is mapped 1 cM centromeric to H-2K . Immunogenetics 27, 57–60 (1988). https://doi.org/10.1007/BF00404445
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DOI: https://doi.org/10.1007/BF00404445