Abstract
A series of antihistamines representing many structural types and pharmacological spectra antagonized isolation-induced fighting in mice. Antagonism of fighting by these compounds was correlated with anti-cholinergic potency as measured by prevention of physostigmine-induced lethality but did not correlate with antihistaminic or anti-tetrabenazine potency. Antagomism of fighting was not related to effects of these drugs on spontaneous motor activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Barnett, A., Taber, R. L., Roth, F. E.: Activity of antihistamines in laboratory antidepressant tests. Int. J. Neuropharmacol. 8, 73–79 (1969).
Collier, H. O. J., Dineen, L. C., Johnson, C. A., Schneider, C.: The abdominal constriction response and its suppression by analgesic drugs in the mouse. Brit. J. Pharmacol. 32, 295–310 (1968).
DaVanzo, J. P., Daugherty, M., Ruckart, R., Kang, L.: Pharmacological and biochemical studies in isolation-induced fighting mice. Psychopharmacologia (Berl.) 9, 210–219 (1966).
Finney, D. J.: Statistical Method in Biological Assay, 2nd ed., pp. 48–64. New York: Hafter 1964.
Goldstein, L., Murphree, H. B., Pfeiffer, C. C.: Comparative study of EEG effects of antihistamines in normal volunteers. J. clin. Pharmacol. 9, 42–53 (1968).
Janssen, P. A. J., Jageneau, A. H., Niemegeers, C. J. E.: Effects of various drugs on isolation-induced fighting behavior of male mice. J. Pharmacol. exp. Ther. 129, 471–475 (1960).
Roth, F. E., Tabachnick, I. I. A.: Histamine and antihistamines. In J. R. DiPalma, (ed.): Drill's Pharmacology in Medicine, pp. 763–785. New York: McGraw-Hill Book Co. 1965.
Siegel, S.: Non-parametric Statistics, pp. 202–213. New York: McGraw-Hill 1956.
Smith, D. E., King, M. B., Hoebel, B. G.: Lateral hypothalamic control of killing: evidence for a cholinoceptive mechanism. Science 167, 900–901 (1970).
Winter, C. A.: The potentiating effect of antihistaminic drugs upon the sedative action of barbiturates. J. Pharmacol. exp. Ther. 94, 7–11 (1948).
Yen, C. Y., Stonger, R. L., Millman, N.: Ataraotic suppression of isolation-induced aggressive behavior. Arch. int. Pharmacodyn. 123, 179–185 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barnett, A., Malick, J.B. & Taber, R.I. Effects of antihistamines on isolation-induced fighting in mice. Psychopharmacologia 19, 359–365 (1971). https://doi.org/10.1007/BF00404380
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00404380