Abstract
Rats trained in conditioned avoidance responding (CAR) after injections of diazepam, 10 mg/kg, showed little or no transfer when tested in the non-drugged state. In this moderate dose diazepam did not significantly facilitate the acquisition of CAR nor did it decrease already established avoidance behavior.
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References
Bloch, S., Silva, A.: Factors involved in the acquisition of a maze habit, analyzed by means of tranquilizing and sedative drugs. J. comp. physiol. Psychol. 52, 550–554 (1959).
Herz, A.: Drugs and the conditioned avoidance response. In: C. C. Pfeiffer and J. R. Smythies (Ed.): International review of neurobiology, Vol. 2. New York: Academic Press 1960.
Kamano, D. K., Arp, D. J.: Effects of chlordiazepoxide (Librium) on the acquisition and extinction of avoidance responses. Psychopharmacologia (Berl.) 6, 112–119 (1964).
Overton, D. A.: State-dependent learning produced by depressant and atropinelike drugs. Psychopharmacologia (Berl.) 10, 6–31 (1966).
Randall, L. O.: Pharmacology of chlordiazepoxide (Librium). Dis. nerv. System. (Suppl.) 22, 1–9 (1961).
—, Heise, G. A., Schallek, W., Bagdon, R. E., Banziger, R., Boris, A., Moe, R. A., Abrams, W. B.: Pharmacological and clinical studies on Valium, a new psychotherapeutic agent of the benzodiazepine class. Curr. ther. Res. 3, 405–425 (1961).
—, Scheckel, C. L., Banziger, R. F.: Pharmacology of the metabolites of chlordiazepoxide and diazepam. Curr. ther. Res. 7, 590–606 (1965).
Sachs, E., Weingarten, M., Klein, N. W., Jr.: Effects of chlordiazepoxide on the acquisition of avoidance learning and its transfer to the normal state and other drug conditions. Psychopharmacologia (Berl.) 9, 17–30 (1966).
Siegel, S.: Nonparametric statistics for the behavioral sciences, pp. 116–127. New York-Toronto-London: McGraw-Hill 1956.
Xhenseval, B.: Action comparée du méprobamate et du diazépam sur le comportement conditionné chez le rat. J. Physiol. (Paris) 56, 465–466 (1964).
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This research was supported in part by the Swedish Medical Research Council (B71-27P-2904-02).
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Henriksson, B.G., Järbe, T. Effects of diazepam on conditioned avoidance learning in rats and its transfer to normal state conditions. Psychopharmacologia 20, 186–190 (1971). https://doi.org/10.1007/BF00404372
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DOI: https://doi.org/10.1007/BF00404372