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Cold-induced Raynaud's phenomenon ameliorated by intravenous administration of ketanserin: a double-blind cross-over study

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Summary

Fifteen patients suffering from Raynaud's phenomenon (RP) were exmined. They were placed in a “climate, chamber” (a small room in which the temperature and humidity could be varied). The temperature was gradually decreased, while the humidity was kept constant. After 60–90 min, distinct RP was induced and intravenous medication was administered. The whole trial was performed in a double-blind, crossover fashion. Every patient participated in two experiments performed 2 days apart. Either ketanserin or placebo was given during the first experiment. In the second experiment, the medication (or placebo) which had not been given was administered. The effects of ketanserin were highly significant: the bluish pallor changed into bright erythema and the skin temperature rose significantly. This was interpreted as a spasmolytic effect. Intravenously administered ketanserin has a place in the clinical treatment of acutely deteriorating RP of diverse etiologies.

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Authors and Affiliations

  1. Department of Dermatology, University Hospital Utrecht, Catharijnesingel 101, NL-3511 GV, Utrecht, The Netherlands

    H. Baart de la Faille & H. van Weelden

  2. Department of Internal Medicine, University Hospital Utrecht, Catharijnesingel 101, NL-3511 GV, Utrecht, The Netherlands

    J. D. Banga & R. G. van Kesteren

Authors
  1. H. Baart de la Faille
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  2. H. van Weelden
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  3. J. D. Banga
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  4. R. G. van Kesteren
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de la Faille, H.B., van Weelden, H., Banga, J.D. et al. Cold-induced Raynaud's phenomenon ameliorated by intravenous administration of ketanserin: a double-blind cross-over study. Arch Dermatol Res 279, 3–7 (1986). https://doi.org/10.1007/BF00404349

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  • DOI: https://doi.org/10.1007/BF00404349

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