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Effective serum concentration and action in pharmacokinetics

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Summary

A formula has been derived for the calculation of “effective” serum concentration based on the assumption of both exponential absorption and exponential elimination of an administered drug. In order to permit quantitative comparisons of different drugs and/or different dosage schedules, a new term is proposed called “action” or “COTT” (for “concentration times time”).

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References

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Authors and Affiliations

  1. Strahlenklinik und -Institut, Abt. Body Counter/Elektronenrechner, Klinikum Steglitz, Freie Universität, Berlin, Deutschland

    P. Koeppe

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  1. P. Koeppe
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Additional information

This paper is dedicated to Prof. Heinz Oeser, M. D., on his 60th birthday.

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Koeppe, P. Effective serum concentration and action in pharmacokinetics. Pharmacol. Clin. 2, 203–205 (1970). https://doi.org/10.1007/BF00404301

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  • DOI: https://doi.org/10.1007/BF00404301

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