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The effect of perphenazine on the ACTH release induced by neurotropic stress

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Summary

In the present work the effect of both acute and chronic perphenazine treatment on the ACTH release induced by neurotropic stress has been studied. Adrenal ascorbic acid depletion was used as an indicator of the ACTH release. It was found that perphenazine was able in acute experimental conditions to inhibit exceedingly strong adrenal ascorbic acid depletion produced by neurotropic stress although in the perphenazine plus stress group the ascorbic acid content of the adrenals was significantly lower than in the intact controls. When perphenazine was administered daily during a longer period, the drug was no longer able on the ninth day of treatment to prevent the ACTH release and adaptation has thus occurred in this respect. Perphenazine was not able to prevent the adrenal ascorbic acid depletion induced by exogenous ACTH and pitressin. On the other hand it was observed that the perphenazine treatment in itself caused slight adrenal ascorbic acid depletion. The possible mechanisms of the action of perphenazine on the release of ACTH have been discussed in the light of previous results and those obtained in the present investigation.

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Authors and Affiliations

  1. Department of Anatomy, University of Turku, Turku, Finland

    E. Kivalo & U. K. Rinne

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  1. E. Kivalo
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  2. U. K. Rinne
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Aided by a grant from the Sigrid Jusélius Stiftelse.

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Kivalo, E., Rinne, U.K. The effect of perphenazine on the ACTH release induced by neurotropic stress. Psychopharmacologia 1, 288–293 (1960). https://doi.org/10.1007/BF00404226

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  • DOI: https://doi.org/10.1007/BF00404226

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