Summary
Twenty phenothiazine compounds with various substitutions at position 2 and 10 of the nucleus were tested for blockade of apomorphine induced pecking in pigeons.
The requirements for maximal activity were -COCH2CH3 substitution at position 2 and a substituted piperazinopropyl group at position 10 of the phenothiazine nucleus.
The anti-pecking activity of phenothiazine parallels the blockade of conditioned avoidance response by them. There is lesser correlation between antipecking and antiemetic activities of phenothiazines.
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Gupta, G.P., Dhawan, B.N. Blockade of apomorphine pecking with phenothiazines. Psychopharmacologia 8, 120–130 (1965). https://doi.org/10.1007/BF00404172
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DOI: https://doi.org/10.1007/BF00404172