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Effects of lysergic acid diethylamide on attack behavior of male albino mice

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Summary

These studies showed that the time of maximum inhibitory effect of LSD-25 on the isolation-induced attack behavior of 11 weeks old Swiss-Webster male mice is 5 min after its intraperitoneal injection. A dose-response study of the inhibitory effect of this compound on 120 mice tested at the time of maximum effect showed that the median ED50 is 0.265 mg/kg (0.212–0.331 mg/kg). A second dose-response study on similar mice, tested 15 min post-injection, indicated that the median ED50 is 0.365 mg/kg (0.261–0.511 mg/kg). All studies showed that LSD-25 given intraperitoneally to mice inhibits their attack behavior.

Résumé

Ces études, effectués sur souris males Swiss-Webster, agées de 11 semaines, ont montré que le temps d'effet inhibiteur maximum du LSD-25 sur le comportement d'attaque induit par l'isolement, est de 5 minutes après injection intrapéritonéale. Une étude dose-réponse de l'effet inhibiteur de ce produit, testé sur 120 souris au temps d'effet maximum, a montré que le médian ED50 est 0,265 mg/kg (0,212–0,331 mg/ kg.). Une seconde étude dose-réponse sur des souris semblables, testées quinze minutes après injection, a indiqué que le médian ED50 est 0,365 mg/kg (0,261–0,511 mg/kg). Toutes études ont montré que le LSD-25, administré intrapéritonéalement aux souris, inhibe leur comportement d'attaque.

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Authors and Affiliations

  1. Life Sciences Research, Stanford Research Institute, Menlo Park, California

    Edward T. Uyeno & Wilbur M. Benson

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  1. Edward T. Uyeno
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  2. Wilbur M. Benson
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Additional information

This work was supported by Grant MH-06655-01A1, National Institutes of Health, U.S. Public Health Service. We gratefully acknowledge supplies of LSD-25 from Dr. C. Orvis and Mr. H. Althouse of Sandoz Pharmaceuticals, Inc. Reproduction in whole or in part is permitted for any purpose of the United States Government.

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Uyeno, E.T., Benson, W.M. Effects of lysergic acid diethylamide on attack behavior of male albino mice. Psychopharmacologia 7, 20–26 (1965). https://doi.org/10.1007/BF00404161

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  • DOI: https://doi.org/10.1007/BF00404161

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