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Die Wirkung des Chlorpromazins auf den Kohlenhydratstoffwechsel des Rattengehirns

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Summary

The effect of chlorpromazine [2-chlor (3-dimethylamino-3′-propyl) 10-phenothiazin] on the glycogen content and the level of the reducing substances has been studied in the rat brain during acute and chronic experiments.

The single dose of 0,35 mg/100 g chlorpromazine given intraperitoneally elevates the level of the reducing substances significantly, while the glycogen content remains unchanged.

After the treatment for two weeks with the dosage of 0,10 mg/100 g per day results a significant increase in the level of the reducing substances and an unchanged quantity of glycogen.

After the treatment for 4 weeks, the level of the reducing substances decreases significantly; at the same time the glycogen content raises above the control value significantly.

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Authors and Affiliations

  1. Biochemischen Laboratorium des Zentralinstituts für Nerven- und Geisteskrankheiten, Budapest

    V. Máthé, Gy. Kassay & K. Hunkár

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  1. V. Máthé
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  2. Gy. Kassay
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  3. K. Hunkár
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Máthé, V., Kassay, G. & Hunkár, K. Die Wirkung des Chlorpromazins auf den Kohlenhydratstoffwechsel des Rattengehirns. Psychopharmacologia 2, 334–341 (1961). https://doi.org/10.1007/BF00404121

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  • DOI: https://doi.org/10.1007/BF00404121

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