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Increased resistance-to-extinction of an avoidance response in rats following the administration of hashish resin

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Abstract

Thirty rats were trained to avoid shock in an automated apparatus and were then given extinction trials with the shocker disconnected. Ss were divided into three groups prior to extinction and given an intra-peritoneal injection of either one of two doses of hashish resin or the vehicle used to dissolve it. Both doses of hashish resin were found to significantly increase the number of trials required to reach the extinction criterion as compared to the placebo group. The higher of the two doses also induced a significant increase in spontaneous recovery responding one day later. The results were compared to a similar finding obtained with alcohol (Baum, 1969, 1970).

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References

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Authors and Affiliations

  1. McGill University, Canada

    Peter G. Jaffe & Morrie Baum

  2. Bishop's University, Canada

    Peter G. Jaffe & Morrie Baum

Authors
  1. Peter G. Jaffe
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  2. Morrie Baum
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Additional information

This research was supported by a grant (No. APA-253) to Morrie Baum from the National Research Council of Canada. The authors are indebted to Dr. A. B. Morrison and Mr. Graham of the Canadian Food and Drug Directorate for providing the hashish resin, and to Fred Saleh and Saleh Saleh for assistance in discovering a suitable solvent for the resin.

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Jaffe, P.G., Baum, M. Increased resistance-to-extinction of an avoidance response in rats following the administration of hashish resin. Psychopharmacologia 20, 97–102 (1971). https://doi.org/10.1007/BF00404064

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  • DOI: https://doi.org/10.1007/BF00404064

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