A simple and reliable conflict procedure for testing anti-anxiety agents


The effects of three benzodiazepines (chlordiazepoxide, diazepam, and oxazepam), meprobamate, pentobarbital, d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide were studied with a simple conflict procedure in which thirsty naive rats were periodically administered shocks for licking water. The results indicated that this simple procedure clearly demonstrated “anti-anxiety” (i.e., increases in punished responding) effects with benzodiazepines, meprobamate and pentobarbital. Doses of d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide did not increase responding.

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Vogel, J.R., Beer, B. & Clody, D.E. A simple and reliable conflict procedure for testing anti-anxiety agents. Psychopharmacologia 21, 1–7 (1971). https://doi.org/10.1007/BF00403989

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  • Benzodiazepines
  • Minor Tranquilizers
  • Conflict
  • Anti-Anxiety
  • Psychopharmacological Procedures