Summary
The distribution of i.v.-injected tritiated oxypertine was studied in mice and cats by an autoradiographic technique. The compound rapidly accumulated in the lung, kidney, liver, adrenal medulla and brain. Later on the radioactivity concentrated also in bone marrow, pancreas and salivary glands, and still more in the gall-bladder and gastro-intestinal contents. The adrenal medulla, liver and kidney retained their activity for a long time. The hippocampus, thalamus and cerebral cortex were the most active sites in the brain. Oxypertine passed the placental barrier and was found especially in the foetal membranes and placenta and in the liver and gut contents of the foetus.
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Airaksinen, M.M., Idänpään-Heikkilä, J.E. Radioautographic study on the distribution of oxypertine (Win 18,501) in mice and cats. Psychopharmacologia 10, 400–408 (1967). https://doi.org/10.1007/BF00403980
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DOI: https://doi.org/10.1007/BF00403980