Abbreviations
- IVGTT:
-
Intravenous glucose tolerance test
- SG :
-
glucose effectiveness
- SI :
-
insulin sensitivity
- NIDDM:
-
non-insulin-dependent diabetes mellitus
References
Bergman RN, Ider YZ, Bowden CR, Cobelli C (1979) Quantitative estimation of insulin sensitivity. Am J Physiol 236: E667-E677
Bergman RN, Phillips NLS, Cobelli C (1981) Physiologic evaluation of factors controlling glucose tolerance in man. Measurement of insulin sensitivity and beta-cell sensitivity from the response to intravenous glucose. J Clin Invest 68: 1456–1467
Cobelli C, Pacini G, Toffolo G, Sacca L (1986) Estimation of insulin sensitivity and glucose clearance from minimal model: new insights from labeled IVGTT. Am J Physiol 250: E591-E598
Caumo A, Giacca A, Morgese M, Pozza G, Micossi P, Cobelli C (1991) Minimal model of glucose disappearance: lessons from the labelled IVGTT. Diabet Med 8: 822–832
Caumo A, Cobelli C (1993) Hepatic glucose production during the labeled IVGTT: estimation by deconvolution with a new minimal model. Am J Physiol 264: E829-E841
Quon MJ, Cochran C, Taylor SI, Eastman RC (1994) Non-insulin mediated glucose disappearance in subjects with IDDM: discordance between experimental results and minimal model analysis. Diabetes 43: 890–896
Saad MF, Anderson RL, Laws A et al. for the IRAS (1994) A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Diabetes 43: 1114–1121
Radziuk J, Norwich KH, Vranic M (1978) Experimental validation of measurements of glucose turnover in non-steady state. Am J Physiol 234: E84-E93
Cobelli C, Toffolo G, Ferrannini E (1984) A model of glucose kinetics and their control by insulin, compartmental and noncompartmental approaches. Math Biosci 72: 291–315
Cobelli C, Mari A, Ferrannini E (1987) Non-steady-state: error analysis of Steele's model and developments for glucose kinetics. Am J Physiol 252: E679-E689
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Caumo, A., Vicini, P. & Cobelli, C. Is the minimal model too minimal?. Diabetologia 39, 997–1000 (1996). https://doi.org/10.1007/BF00403922
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DOI: https://doi.org/10.1007/BF00403922