Summary
We compared the Danish 8-MOP brand Meladinine with the Austrian brand Oxsoralen because of our discouraging result with PUVA in treating psoriasis. Nine healthy volunteers participated in the investigation. The plasma level of 8-MOP was measured by a gas chromatographic-mass spectrometric method using isotopic dilution technique. The level obtained with Oxsoralen was on the average 5.8 times higher than that with Meladinine.
zusammenfassung
Aufgrund unserer negativen Resultate bei der photochemoterapeutischen Behandlung von Psoriasis haben wir das dänische Medikament 8-MOP Meladinine mit dem österreichischen Oxsoralen verglichen. Neun Versuchspersonen nahmen an der Untersuchung teil. Die Plasmakonzentration von 8-MOP wurde durch eine gas-chromatographisch-massenspektrometrische Methode mit Hilfe einer Isotopverdünnungsanalyse bestimmt. Die Plasmakonzentration mit Oxsoralen waren durchschnittlich 5,8mal höher als die mit Meladinine erhaltenen Konzentrationen.
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Andersen, K.E., Menne, T., Gammeltoft, M. et al. Pharmacokinetic and clinical comparison of two 8-methoxypsoralen brands. Arch Dermatol Res 268, 23–29 (1980). https://doi.org/10.1007/BF00403883
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DOI: https://doi.org/10.1007/BF00403883