Summary
The kinetics of migration of radiolabeled 8-methoxypsoralen into human cataract lenses were investigated in 12 patients undergoing operation. Lenses were examined from 2.5–72 h after intake of 3H-labeled 8-methoxypsoralen by mouth. Demonstrable amounts of activity was only found in two of three lenses studied 24 h after intake. The aqueous humor contained less 8-methoxypsoralen than serum. The results of the study may add support to the opinion that a less rigorous sunglass regimen than that recommended by certain PUVA centers may be justified.
Zusammenfassung
Die Kinetik der Migration von radiomarkiertem 8-Methoxypsoralen in menschliche Katarakt-Linsen wurde bei 12 Patienten untersucht, deren Linsen operative entfernt wurden. Die Linsen wurden 2,5 bis 72 h nach Aufnahme von 3H-markiertem 8-Methoxypsoralen oral geprüft. Deutliche Mengen einer Radioaktivität wurden lediglich in zwei von drei Linsen gefunden, die 24 h nach oraler Aufnahme untersucht wurden. Wäßrige Flüssigkeit enthielt weniger 8-Methoxypsoralen als das Serum. Diese Resultate unterstützen die Annahme, daß eine weniger rigorose Verordnung von Augenschutz durch Sonnenbrillen notwendig ist, wie es von manchen PUVA-Behandlungszentren empfohlen wird.
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Marqversen, J., Axelsen, I., Nielsen, E. et al. 8-Methoxypsoralen and the eye. Arch Dermatol Res 270, 387–390 (1981). https://doi.org/10.1007/BF00403782
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DOI: https://doi.org/10.1007/BF00403782