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Flurothyl toxicity: a remarkable species difference between chick and mouse

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Summary

Young chicks survive flurothyl vapor concentrations that are lethal to mice. For a 10-min exposure, the LD50 concentrations (% v/v) of flurothyl are 10.1% in chicks and 0.33% in mice; the convulsant concentrations (CD50) are 0.49% in chicks and 0.32% in mice. The remarkable resistance of young chicks to flurothyl toxicity may be related to their known resistance to hypoxic death.

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Authors and Affiliations

  1. Psychobiology Research Laboratory, Veterans Administration Hospital, 91343, Sepulveda, California, USA

    Arthur Cherkin

  2. Division of Anesthesia, University of California School of Medicine, 90024, Los Angeles, California, USA

    Arthur Cherkin

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  1. Arthur Cherkin
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Cherkin, A. Flurothyl toxicity: a remarkable species difference between chick and mouse. Psychopharmacologia 15, 404–407 (1969). https://doi.org/10.1007/BF00403715

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  • DOI: https://doi.org/10.1007/BF00403715

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