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Psychopharmacologia

, Volume 15, Issue 5, pp 373–381 | Cite as

Effects of serotonin depletion on the volitional alcohol intake of rats during a condition of psychological stress

  • R. D. Myers
  • T. J. Cicero
Original Investigations

Summary

Non-preferred solutions of ethyl alcohol, that were slightly above preference threshold, were offered together with water to rats which were trained to avoid foot shock by pressing a lever. Intake of alcohol increased significantly when the rats were stressed by intermittent, random unavoidable shock. When levels of brain serotonin were lowered by p-chlorophenylalanine (pCPA), a potent inhibitor of tryptophan hydroxylase, the selection of alcohol declined during the period of random punishment to the pre-stress baseline intakes. The depletion of serotonin during the stress period reduced alcohol preference particularly in those rats which drank the largest amounts of alcohol. These findings extend those of an earlier report that pCPA lowers alcohol intake in non-stressed rats which drank alcohol solutions within the normal range of preference.

Key-Words

Serotonin in Brain Stress and Alcohol Intake Alcohol Preference and Serotonin 5-hydroxytryptamine and Alcohol 

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References

  1. Bonnycastle, D. D., M. F. Bonnycastle, and E. G. Anderson: The effect of a number of central depressant drugs upon brain 5-hydroxytryptamine levels in the rat. J. Pharmacol. exp. Ther. 135, 17–20 (1962).Google Scholar
  2. Cicero, T. J., and R. D. Myers: Selection of a single ethanol test solution in freechoice studies with animals. Quart. J. Stud. Alcohol. 29, 446–448 (1968a).Google Scholar
  3. — —: Facilitation of discriminated avoidance learning by prior operant training Psychol. Rep. 22, 1273–1276 (1968b).Google Scholar
  4. — — and W. C. Black: Increase in volitional ethanol consumption following interference with a learned avoidance response. Physiol. Behav. 3, 657–660 (1968).Google Scholar
  5. Davis, V. E., H. Brown, J. A. Huff, and J. L. Cashaw: The alteration of serotonin metabolism to 5-hydroxytryptophol by ethanol ingestion in man. J. Lab. clin. Med. 69, 132–140 (1967).Google Scholar
  6. Feldstein, A., H. Hoagland, H. Freeman, and O. Williamson: The effect of ethanol ingestion on serotonin-C14 metabolism in man. Life Sci. 6, 53–61 (1967).Google Scholar
  7. Gursey, D., and R. E. Olson: Depression of serotonin and norepinephrine levels in brain stem of rabbit by ethanol. Proc. Soc. exp. Biol. (N. Y.) 104, 280–281 (1960).Google Scholar
  8. Koe, B., and A. Weissman: p-Chlorophenylalanine: A specific depletor of brain serotonin. J. Pharmacol. exp. Ther. 154, 499–516 (1966).Google Scholar
  9. Myers, R. D.: Alcohol consumption in rats: Effects of intracranial injections of ethanol. Science 142, 240–241 (1963).Google Scholar
  10. —: Voluntary alcohol consumption in animals: Peripheral and intracerebral factors. Psychosom. Med. 28, 484–497 (1966).Google Scholar
  11. —: Ethyl alcohol consumption: Valid measurement in albino rats. Science 161, 76–77 (1968).Google Scholar
  12. —, and R. B. Holman: A procedure for eliminating position habit in preference-aversion tests for ethanol and other fluids. Psychon. Sci. 6, 235–236 (1966).Google Scholar
  13. —, and R. B. Holman: Failure of stress of electric shock to increase ethanol intake in rats. Quart. J. Stud. Alcohol 28, 132–137 (1967).Google Scholar
  14. —, and W. L. Veale: Alcohol preference in the rat: Reduction following depletion of brain serotonin. Science 160, 1469–1471 (1968).Google Scholar
  15. Pscheidt, G. R., B. Issekutz, and H. E. Himwich: Failure of ethanol to lower brain stem concentration of biogenic amines. Quart. J. Stud. Alcohol 22, 550–553 (1961).Google Scholar
  16. Rech, R. H., H. K. Borys, and K. E. Moore: Alterations in behavior and brain catecholamine levels in rats treated with α-methyltyrosine. J. Pharmacol. exp. Ther. 153, 412–419 (1966).Google Scholar
  17. Shore, P. A., A. Pletscher, E. Tomich, A. Carlsson, R. Kuntzman, and B. Brodie: Role of brain serotonin in reserpine actions. Ann. N.Y. Acad. Sci. 66, 609–617 (1957).Google Scholar
  18. Spector, S., A. Sjoerdsma, and S. Udenfriend: Blockade of endogenous norepinephrine synthesis by a-methyl-tyrosine, an inhibitor of tyrosine hydroxylase. J. Pharmacol. exp. Ther. 147, 86–95 (1965).Google Scholar

Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • R. D. Myers
    • 1
  • T. J. Cicero
    • 1
  1. 1.Laboratory of NeuropsychologyPurdue UniversityLafayette

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