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Amphetamine, scopolamine and chlorpromazine interactions on delayed matching performance in monkeys

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Summary

Two drug combinations, amphetamine-chlorpromazine and amphetamine-scopolamine, were examined in monkeys performing on a delayed matching test. Antagonism between the effects of amphetamine and chlorpromazine on both response rate and accuracy measures of performance was found. Amphetamine and scopolamine had antagonistic effects on response rate but synergistic effects on accuracy.

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Authors and Affiliations

  1. Department of Pharmacology, Albert Einstein College of Medicine, Bronx, N. Y.

    Stanley D. Glick & Murray E. Jarvik

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  1. Stanley D. Glick
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  2. Murray E. Jarvik
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Additional information

Supported by Public Health Service Grant MH 01225. The authors wish to thank Mr. Bruce Levin for performing the computer analysis using the facilities of the Albert Einstein College of Medicine Computer Center. We also wish to thank Mrs. Toni Goldfarb, Mr. Jay Carley and Mr. Richard Pybus for indispensable technical assistance.

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Glick, S.D., Jarvik, M.E. Amphetamine, scopolamine and chlorpromazine interactions on delayed matching performance in monkeys. Psychopharmacologia 16, 147–155 (1969). https://doi.org/10.1007/BF00403617

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  • DOI: https://doi.org/10.1007/BF00403617

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