Summary
Monkeys were trained in the performance of a matching from sample task and in two simultaneous visual discrimination tasks differing in level of difficulty. In the case of the matching task, four doses each of chlorpromazine and of secobarbital were administered to the animals according to a balanced design. The procedure was then replicated. The results of the matching task indicated that chlorpromazine produced many errors of omission and few errors of commission. The latter kind of error as well as other measures of confused responding were seen primarily with secobarbital. In the case of the visual discriminations, secobarbital produced greater impairment of the more difficult (pattern) task than of the simpler (color) task; chlorpromazine had equivalent effects on the two tasks. The similarity between the secobarbital action and the behavioral consequences of certain cortical lesions in the monkey was discussed.
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References
Brazier, M. A. B.: The action of anesthetics on the nervous system. In: E. D. Adrian and H. H. Jasper (Eds.), Brain mechanisms and consciousness. Springfield (Ill.): Ch. C. Thomas 1954.
Drachman, D. A., Ommaya, A. K.: Memory and the hippocampal complex. Arch. Neurol. 10, 411–425 (1964).
Geisser, S., Greenhouse, S. W.: An extension of Box's results on the use of the F distribution in multivariate analysis. Ann. Math. Stat. 29, 885–891 (1958).
Kornetsky, C., Orzack, M. H.: A research note on some of the critical factors on the dissimilar effects of chlorpromazine and secobarbital on the Digit Symbol Substitution and Continuous Performance Tests. Psychopharmacologia (Berl.) 6, 79–86 (1964).
Lansdell, H., Mirsky, A. F.: Attention in focal and centrencephalic epilepsy. Exp. Neurol. 9, 463–469 (1964).
Lindquist, E. F.: Design and analysis of experiments in psychology and education. Boston: Houghton Mifflin 1956.
Mann, H. B., Whitney, D. R.: On a test of whether one of two random variables is stochastically larger than the other. Ann. Math. Stat. 18, 50–60 (1947).
Mirsky, A. F., Bakay Pragay, E.: EEG characteristics of impaired attention accompanying secobarbital and chlorpromazine administration in monkeys. In: D. I. Mostofsky (Ed.), Attention: Contemporary theory and analysis. New York: Appleton-Century-Crofts (in press).
—, Bloch, S.: Effects of chlorpromazine, secobarbital and sleep deprivation on attention in monkeys. Psychopharmacologia (Berl.) 10, 388–399 (1967).
—, Cardon, P. V.: A comparison of the behavioral and physiological changes accompanying sleep deprivation and chlorpromazine administration in man. Electroenceph. clin. Neurophysiol. 14, 1–10 (1962).
—, Kornetsky, C.: On the dissimilar effects of drugs on the Digit Symbol Substitution and Continuous Performance Tests. Psychopharmacologia (Berl.) 5, 161–177 (1964).
, Primac, D. W., Bates, R.: The effects of chlorpromazine and secobarbital on the Continuous Performance Test. J. nerv. ment. Dis. 128, 12–17 (1959).
Mishkin, M.: Visual discrimination performance following partial ablations of the temporal lobe: II. Ventral surface vs. hippocampus. J. comp. physiol. Psychol. 47, 187–193 (1954).
Primac, D. W., Mirsky, A. F., Rosvold, H. E.: Effects of centrally-acting drugs on two tests of brain damage. Arch. Neurol. Psychiat. (Chic.) 77, 328–332 (1957).
Rosvold, H. E., Mirsky, A. F., Sarason, I., Bransome, E. B., Jr., Beck, L. H.: A continuous performance test of brain damage. J. cons. Psychol. 20, 343–350 (1956).
Scheckel, C. L.: The effect of chlorpromazine (thorazine) and chlordiazepoxide (librium) on delayed matching responses in the Macaca mulatta. Ph. D. Dissertation 1963, Fordham University. University Microfilms # 63-5601.
Townsend, A.M., III, Mirsky, A. F.: A comparison of the effects of meprobamate, phenobarbital and d-amphetamine on two psychological tests. J. nerv. ment. Dis. 130, 212–216 (1960).
Wechsler, D.: The measurement of adult intelligence, 3. ed. Baltimore: Williams and Wilkins Co. 1944.
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This work was supported by the following grants from the National Institute of Mental Health, Public Health Service: Research Grant MH-12568; Special Fellowship 1-F3-25,128 (Dr. Bakay Pragay); Research Scientist Award 5-KO-5MH-14,915 (Dr. Mirsky); Predoctoral Fellowship 1-F2-NB-32-103 (Dr. Abplanalp).
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Pragay, E.B., Mirsky, A.F. & Abplanalp, J.M. The effects of chlorpromazine and secobarbital on matching from sample and discrimination tasks in monkeys. Psychopharmacologia 16, 128–138 (1969). https://doi.org/10.1007/BF00403615
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DOI: https://doi.org/10.1007/BF00403615