Summary
F1 hybrids of two highly inbred strains of mice were trained in a one-trial passive avoidance learning situation. Chlorpromazine, in doses of 0.5, 2.0 and 3.5 mg/kg, was administered at one of four injections times, 10 min before and 0.5, 2 and 10 min after learning. Pre-learning drug administration completely blocked acquisition of a learned avoidance response. Post-learning drug effects were more complex, involving reduced expression of avoidance learning but less rapid extinction of the learned response. The results were related to effects of the drug on short-term memory trace decay and consolidation.
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Johnson, F.N. The effects of chlorpromazine on the decay and consolidation of short-term memory traces in mice. Psychopharmacologia 16, 105–114 (1969). https://doi.org/10.1007/BF00403613
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DOI: https://doi.org/10.1007/BF00403613