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Temporary and partial antagonism by l-DOPA of reserpine-induced suppression of a conditioned avoidance response

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Summary

Mice and rats were trained to avoid shock in a modified shuttle box. Following training the animals were treated with reserpine. The suppression of the conditioned avoidance response induced by reserpine was partially and temporarily reversed by an injection of l-3,4-dihydroxyphenylalanine, and the suppression of locomotor activity was completely antagonized for approximately the same duration.

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Authors and Affiliations

  1. Department of Pharmacology, University of Göteborg, Göteborg, Sweden

    Lewis S. Seiden & Arvid Carlsson

Authors
  1. Lewis S. Seiden
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  2. Arvid Carlsson
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Additional information

This investigation supported in part by Postdoctoral Fellowship (MPD-10, 562-C3) from the United States Public Health Service, National Institute of Mental Health.

The authors wish to thank Miss Anne-Charlotte Lilljeqvist for her expert technical assistance.

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Seiden, L.S., Carlsson, A. Temporary and partial antagonism by l-DOPA of reserpine-induced suppression of a conditioned avoidance response. Psychopharmacologia 4, 418–423 (1963). https://doi.org/10.1007/BF00403346

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  • DOI: https://doi.org/10.1007/BF00403346

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