, Volume 34, Issue 7, pp 483–487 | Cite as

Different aetiologies of Type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects

  • P. Arner
  • T. Pollare
  • H. Lithell


Insulin responses to intravenous glucose infusion and glucose utilization during hyperinsulinaemic euglycaemic clamp were determined in a large homogeneous group of 65-year-old male subjects. Twenty-eight had untreated Type 2 (non-insulin-dependent) diabetes mellitus and the remaining 44 control subjects had a normal glucose tolerance. Diabetic patients with abdominal obesity displayed peripheral insulin resistance in combination with defective insulin secretion, whereas non-obese diabetic patients showed only a secretory defect. Thus, Type 2 diabetes in obese and non-obese elderly male subjects may take two forms where the cause of hyperglycaemia differs.

Key words

Insulin glucose obesity glucose disposal insulin secretion 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • P. Arner
    • 1
  • T. Pollare
    • 2
  • H. Lithell
    • 2
  1. 1.Department of Medicine, Huddinge HospitalKarolinska InstituteStockholm
  2. 2.Department of Geriatrics, Kungsgärdets HospitalUppsala UniversityUppsalaSweden

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