Archives of Microbiology

, Volume 97, Issue 1, pp 81–88 | Cite as

Effect of bongkrekic acid on growth and metabolism of filamentous fungi

  • Július Šubík
  • Miroslav Behúň


The antifungal activity of bongkrekic acid against 17 tested molds was determined. Bongkrekic acid prevented spore germination and mycelial proliferation of Aspergillus niger, Rhizopus oryzae and Penicillium italicum. The action of bongkrekic acid was fungicidal. Under these conditions, the incorporation of 14C-leucine and 14C-uracil into the perchloric acid insoluble material of germinating A. niger conidia was significantly reduced by bongkrekic acid. Respiratory activity of resting spores was not affected by bongkrekic acid. Respiratory activity of germinated spores was inhibited by bongkrekic acid to the extent of 30 to 60% of controls for A. niger, R. oryzae and P. italicum. It has been concluded that operation of adenine nucleotide translocation in mitochondria of tested fungi is obligatory both for normal spore germination and fungal growth.

Key words

Bongkrekic Acid Antifungal Antibiotic Fungi Spore Germination Mitochondria Nucleotide Translocation 


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Július Šubík
    • 1
  • Miroslav Behúň
    • 1
  1. 1.Food Research InstituteSlovak Agricultural AcademyBratislava

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