Summary
Cytogenetic studies on neuroblastomas arising in children have revealed consistent abnormalitics of the short arm of chromosome number 1. Partly because of the rare occurence of neuroblastomas in adults, extensive cytogenetic studies in this group of patients have not been performed. We report a case of a neuroepithelioma (neuroblastoma) arising in a 50-year-old male patient. On chromosome analysis of a metastasis, a stemline with karyotype 47,XY, +der1(1 qter... 1 cen::1q21...1 qter) was identified. The possible consequences of this result and those of results previously reported in the literature are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
An international system for human cytogenetic nomenclature (1978) Cytogenet Cell Genet 21:309–404
Atkin NB, Pickthall VL (1977) Chromsome 1 in 14 ovarian cancers. Heterochromatin variants and structural changes. Hum Genet 38:25–33
Balaban G, Gilbert F (1983) Neuroblastoma IV-S: chromosome analysis. N Engl J Med 309:989
Biedler JL, Ross RA, Shanske S, Spengler B (1980) Human neuroblastom cytogenetics: Search for significance of homogeneously staining regions and double minute chromosomes. In: Evans A (ed) Advances in neuroblastoma research. Raven Press, New York, pp 81–96
Bolen, JW, Thorning D (1980) Peripheral neuroepithelioma: A light and electron microscopic study. Cancer 46:2456–2462
Breslow N, McCann B (1971) Statistical estimation of prognosis for children with neuroblastoma. Cancer Res 31:2098–2103
Brito-Babapulle V, Atkin NB (1981) Breakpoints in chromosome 1 abnormalities of 218 human neoplasms. Cancer Genet Cytogenet 4:215–225
Brodeur GM, Sekhon GS, Goldstein MN (1977) Chromsomal aberrations in human neuroblastomas. Cancer 40:2256–2263
Brodeur GM, Green AA, Hayes A et al. (1981) Cytogenetic features of human neuroblastomas and cell lines. Cancer Res 41:4678–4686
Casper JT, Trent JM, Harb J et al. (1983) Distinguishing characteristics of a new neuroblastoma cell line. Cancer Genet Cytogenet 10:177–186
Cowell JK, Rupniak T (1983) Chromosome analysis of human neuroblastoma cell line TR 14 showing double minutes and an aberration involving chromosome 1. Cancer Genet Cytogenet 8:273–280
De Martinville B, Cunningham JM, Murray MJ, Fracke U (1984) The N-ras oncogene assigned to chromosome 1 (p31---cen) by somatic cel hybrid analysis. Cytogenet Cell Genet 37:531
Dosik GM, Rodriguez V, Benjamin RS, Bodey GP (1978) Neuroblastoma in the adult. Cancer 41:56–63
Evans A, D'Angio GJ, Finklestein JZ et al. (1976) Factors influencing survival of children with nonmetastatic neuroblastoma. Cancer 38:661–666
Fox F, Davidson J, Thomas LB (1959) Maturation of sympathicoblastoma into ganglioneuroma. Cancer 12:108–116
Franke U, de Martinville B, Coussens L, Ulrich A (1983) The human gene for the beta-subunit of nerve growth factor is located on the proximal short arm of chromosome 1. Science 222:1248–1251
Gilbert F, Balaban G, Moorhead P et al. (1982) Abnormalities of chromosome 1p in human neuroblastoma tumors and cell lines. Cancer Genet Cytogenet 7:33–42
Haag MM, Soukup SW, Neely JE (1981) Chromosome analysis of a human neuroblastoma. Cancer Res 41:2995–2999
Harkin JC, Reed RJ (1969) Tumours of the peripheral nervous system. Atlas of Tumour Pathology. Second series. Fascicle 3. Washington DC: Armed Forces Institute of Pathology
Harper PG, Pringle J, Souhami RL (1981) Neuroepithelioma —a rare malignant peripheral nerve tumor of primitive origin. Cancer 48:2282–2287
Hashimoto H, Kirya H, Enjoj M, Daimaru Y, Nakajima T (1983) Malignant neuroepithelioma (periferal neuroblastoma). Am J Surg Pathol 7:309–318
Ishikawa S, Ohshima Y, Suzuki T, Oboshi S (1979) Primitive neuroectodermal tumor (neuroepithelioma) of spinal nerve root. Acta Pathol 29:289–301
Knudson AG, Strong L (1972) Mutation and cancer: Neuroblastoma and pheochromocytoma. Am J Hum Genet 24:514–532
Kovacs G (1979) Homogenously staining regions on marker chromosomes in malignancy. Int J Cancer 23:299–301
Lopez R, Karakousis C, Rao U (1980) Treatment of adult neuroblastoma. Cancer 45:840–844
Mackay B, Luna MA, Butler JJ (1976) Adult neuroblastoma. Cancer 37:1334–1351
Morse H, Hays T, Rose B, Robinson A (1979) Chromosome 1 abnormalities in relapse and terminal stages in childhood leukemia. Med Pediatr Oncol 7:9–16
Morton CC, Taub R, Diamond A (1984) Mapping of the human Blym-1 transforming gene activated in Burkitt lymphomas to chromosome 1. Science 223:173–175
Nesbitt KA, Vidone RA (1976) Primitive neuroectodermal tumor (neuroblastoma) arising in sciatic nerve of a child. Cancer 37:1562–1570
Ninfo V, Zikotto GR (1973) Il neuroepitelioma maligno dei nervi periferici (cosidetto medulloblastoma dei nervi periferici). Pathologia 65:393–397
Philips R (1953) Neuroblastoma: Hunterian lecture. Ann Royal Coll Surgeons England 12:28–48
Rowley JD (1977) Mapping of human chromosomal regions related to neoplasia: evidence from chromosomes 1 and 17. Proc Natl Acad Sci USA 74:5729–5733
Sandberg AA (1980) Solid tumors and metastatic cancer. In: The chromosomes in human cancer and leukemia. Elsevier North Holland, Amsterdam, p 458–565
Stout AP (1918) A tumor of ulnar nerve. Proc NY Pathol Soc 18:2–13
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Verwey, J., Slater, R., Kamphorst, W. et al. Neuroepithelioma (neuroblastoma) arising in an adult. J Cancer Res Clin Oncol 110, 165–169 (1985). https://doi.org/10.1007/BF00402733
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00402733