Summary
This paper reports the results of the EBV-specific antibody response in 17 Italian nasopharyngeal carcinoma (NPC) patients, 15 other head and neck tumor patients and 15 normal controls. Nucleic acid hybridization has been performed on the biopsy tissue from 4 of the NPC patients, and EBV-DNA was present in two undifferentiated (WHO 3) tumors, and absent in two samples of the keratinizing (WHO 1) type. EBV serology appears to be specifically related to NPC, more evidently for VCA-IgA and EA-IgG antibodies, and useful as an aid in diagnosis of NPC. However, in order to assess a prognostic value of the above markers, a greater number of patients followed for a longer period of time (at least 5 years) is needed, and is currently being pursued.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ablashi DV, Allal L, Armstrong G, Bouguermouh A, Pearson GR, Levine PH, Bengali ZH, Easton JM, Zaghouani S, Chouitier A, Allouache A, Ghoudali R (1981) Some characteristics of nasopharyngeal carcinoma in Algeria. In: Grundmann et al. (eds) Cancer Campaign, vol 5. Nasopharyngeal Carcinoma. Gustav Fischer Verlag, Stuttgart, New York pp 157–167
Ablashi DV, Prasad U, Pearson GR, Prathap K, Armstrong GR, Faggioni A, Yadav M, Easton GM, Chan SH, Levine PH (1983) EBV-related studies with clinico-pathological correlation in Malaysian nasopharyngeal carcinoma. In: Prasad et al. (eds) Nasopharyngeal carcinoma: Current Concepts. University of Malaya. Kuala Lumpur pp 163–171
Cammoun M, Vogt Horner GV, Mourali N (1974) Tumors of the nasopharynx in Tunisia. Cancer 33:184–193
Cheng YC, Chen JY, Glaser R, Henle W (1980) Frequency and levels of antibodies to Epstein-Barr virus specific DNAse are elevated in patients with nasopharyngeal carcinoma. Proc Natl Acad Sci USA, 77:6162–6165
Dalla Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Croce CM (1982) Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt's lymphoma cells. Proc Natl Acad Sci USA 79:7824–7827
De The' G (1980) Role of Epstein-Barr virus in human diseases, Infectious mononucleosis, Burkitt's lymphoma and nasopharyngeal carcinoma. In: Klein G (ed) Viral Oncology, Raven Press, New York, pp 769–797
Epstein MA, Achong BG (1979) The relationship of the virus to Burkitt's lymphoma. In: Epstein MA, Achong BG (eds) The Epstein-Barr virus. Springer Verlag, Berlin, Heidelberg, New York, pp 321–327
Henderson BE, Louie EW, Jing JS, Buell P, Gardner MB (1976) Risk factors associated with nasopharyngeal carcinoma. N Engl J Med 295:1101–1106
Henle G, Henle W, Diehl V (1968) Relation of Burkitt tumor associated herpestype virus to infectious mononucleosis. Proc Natl Acad Sci USA 59:94–101
Henle G, Henle W, Clifford P, Diehl V, Kafuko G, Kirya BG, Klein G, Morrow RH, Manube GMR, Pike P, Tukei PM, Ziegler J (1969) Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups. J Natl Cancer Inst 43:1147–1157
Henle W, Henle G, Ho HC, Burtin P, Cachin Y, Clifford P, De-Schryver A, De The' G, Diehl V, Klein G (1970) Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms and control groups. J Natl Cancer Inst 44:225–231
Henle W, Ho JHC, Henle G, Chau JCW, Kwan HC (1977) Nasopharyngeal carcinoma: significance of changes in Epstein-Barr virus related antibody patterns following therapy. Int J Cancer 20:663–672
Ho JHC (1972) Nasopharyngeal carcinoma (NPC). Adv Cancer Res 15:57–92
Huang DP, Ho HC, Henle W, Henle G, Saw D, Lin M (1978) Presence of EBNA in nasopharyngeal carcinoma and control patients tissues related to EBV serology. Int J Cancer 22:266–274
Kamaraju LS, Levine PH, Sundar SK, Ablashi DV, Faggioni A, Armstrong GR, Bertram G, Krueger GRF (1983) Epstein-Barr virus related lymphocyte stimulation inhibitor: a possible tool for undifferentiated nasopharyngeal carcinoma. J Natl Cancer Inst 70:643–647
Klein G (1979) The relationship of the virus with nasopharyngeal carcinoma. in: Epstein MA, Achon BG (eds) The Epstein-Barr virus. Springer-Verlag, Berlin, Heidelberg, New York, pp 339–350
Kottaridis SD, Dafnou M, Besbeas S, Garas J (1977) Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma and other neoplastic conditions. J Natl Cancer Inst 1:89–91
Mathew GD, Qualtiere LF, Neel HB, Pearson GR (1981) IgA antibody, antibody dependent cellular cytotoxicity and prognosis in patients with nasopharyngeal carcinoma. Int J Cancer 27:175–180
Old J, Boyse EA, Oetgen HF, DeHarven E, Geering G, Williamson B, Clifford P (1966) Precipitating antibody in human serum to an antigen present in cultured Burkitt's lymphoma cells. Proc Natl Acad Sci USA 56:1699–170
Pearson GR (1980) Epstein-Barr virus: Immunology. In: Klein G (ed) Viral Oncology. Raven Press, New York, pp 739–767
Pearson GR, Orr TW (1976) Antibody-dependent lymphocyte cytotoxicity against cells expressing Epstein-Barr virus antigen. J Natl Cancer Inst 56:485–488
Pearson GR, Johanson B, Klein G (1978) Antibody dependent cellular cytotoxicity against Epstein-Barr virus-associated antigens in African patients with nasopharyngeal carcinoma. Int J Cancer 22:120–125
Pearson GR, Weiland LH, Neel B, Taylor W, Earle J, Mulroney S, Goepfert H, Lanier A, Talvot M, Pilch B, Goodman M, Huang A, Levine PH, Hyams V, Moran E, Henle G, Henle W (1983a) Application of Epstein-Barr virus (EBV) serology to the diagnosis of North American nasopharyngeal carcinoma. Cancer 51:260–268
Pearson GR, Taylor WF, Mulroney S, Weiland LH, Neel HB (1983b) Clinical Immunovirology: Current Status. In: Prasad et al. (eds) Nasopharyngeal Carcinoma: Current Concepts. University of Mylaya. Kuala Lumpur pp 87–98
Reedman BM, Klein G (1973) Cellular localization of an EBV-associated complement fixing antigen in producer and nonproducer lymphoblastoid cell lines. Int J Cancer 22:120–125
Saemundsen, KA, Albeck H, Hansen JPH, Nielsen NH, Anvret M, Henle W, Henle G, Thomsen KA, Kristensen HK, Klein G (1982) Epstein-Barr virus in nasopharyngeal and salivary gland carcinomas of Greenland Eskimos. Br J Cancer 46:721–728
Shanmugaratnam K, Sobin LH (1978) Histological typing of upper respiratory tract tumors. International histological classification of tumors, N. 14 (WHO), Geneva
Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503–517
Sundar SK, Menezes J, Levine PH, Ablashi DV, Kamaraju LS, Faggioni A, Prasad U (1983) Relationship of IgA to an EBV-specific lymphocyte stimulation inhibitor (LSI) present in the sera of patients with undifferentiated nasopharyngeal carcinoma. In: Prasad et al. (eds) Nasopharyngeal Carcinoma: Current Concepts. University of Malaya, Kuala Lumpur, pp 293–297
Uhlmann C, Krueger GRF, Sesterhenn K, Rose KG, Ablashi DV, Westrow F (1978) Nasopharyngeal and adjacent neoplasms, a clinico-pathologic and immunologic study. Arch Oto-Rhino-Laryng 218:163–177
Author information
Authors and Affiliations
Additional information
Supported in part by funds from Progetto Finalizzato “Oncologia”. National Research Council, Italy
Rights and permissions
About this article
Cite this article
Faggioni, A., Corradini, C., Barile, G. et al. Epstein-Barr virus serology in nasopharyngeal carcinomas and other head and neck neoplasms in Italy. J Cancer Res Clin Oncol 110, 157–160 (1985). https://doi.org/10.1007/BF00402731
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00402731