Summary
Comparing the radiotherapy data of two groups of patients with non-metastatic Ewing sarcoma, we came to the following conclusions: (1) intensive chemotherapy does not substitute for effective radiotherapy. (2) Irradiation fields should be large enough to include the whole affected bone and the entire extra-osseous compartments, exampting only uninvolved epiphyses. (3) Marginal recurrences are a major risk of the shrinking field technique. (4) Single doses per fraction should be high and the total dose raised to the point of maximal irradiation tolerance of normal tissues.
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Prindull, G., Jürgens, H., Jentsch, F. et al. Radiotherapy of non-metastatic ewing sarcoma. J Cancer Res Clin Oncol 110, 127–130 (1985). https://doi.org/10.1007/BF00402725
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DOI: https://doi.org/10.1007/BF00402725