Summary
A possible relationship between central nervous muscarinic and monoaminergic mechanisms with regard to inhibition of oestrous behaviour in female rats was investigated. Increased central nervous monoaminergic activity brought about by the monoamine oxidase inhibitors nialamide or pargyline or by desmethylimipramine augmented and/or prolonged the heat inhibitory effect of pilocarpine. Parallel studies on body temperature reveal that the synergism is probably not due to a decreased rate of elimination of pilocarpine, at least in the cases of pargyline and desmethylimipramine.
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This work was supported by grants from the Swedish Medical Research Council (No. 14 X-64-04) to Dr. B. Meyerson and the author.
The author wishes to express his gratitude to Dr. B. Meyerson for advice given during the experiments and during the preparation of the manuscript.
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Lindström, L.H. The effect of pilocarpine in combination with monoamine oxidase inhibitors, imipramine or desmethylimipramine on oestrous behaviour in female rats. Psychopharmacologia 17, 160–168 (1970). https://doi.org/10.1007/BF00402706
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DOI: https://doi.org/10.1007/BF00402706