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Retarded depression and the dopamine metabolism

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Abstract

It was demonstrated that the influence of i.v. administered probenecid on HVA concentration in CSF was less pronounced in a group of retarded depression than in a group of non-retarded depression and a non-depressive control group. The figures corresponded to that found in Parkinson patients.

These findings suggest a decreased consumption of dopamine in the brain in retarded depression. This might be understood as an indication that, disorders of cerebral dopamine metabolism are related not so much to a specific nosological entity as to a given motor status, possibly that of hypokinesia.

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Authors and Affiliations

  1. Department of Biological Psychiatry, Psychiatric University Clinic, State University of Groningen, The Netherlands

    H. M. van Praag & J. Korf

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  1. H. M. van Praag
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  2. J. Korf
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Additional information

This study was supported by grants from the Netherlands Organization for Pure Research (Z.W.O.).

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van Praag, H.M., Korf, J. Retarded depression and the dopamine metabolism. Psychopharmacologia 19, 199–203 (1971). https://doi.org/10.1007/BF00402643

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  • DOI: https://doi.org/10.1007/BF00402643

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