Abstract
A multiple fixed-ratio, fixed-interval schedule of food presentation was used to study interactions between naloxone and chlorpromazine in the pigeon. Inactive doses of both drugs could combine to decrease the rate of responding under both schedule components. Inactive doses of naloxone could enhance the rate-decreasing effects of chlorpromazine and inactive doses of chlorpromazine could enhance the rate-decreasing effects of naloxone. When both drugs decreased the rate, the combined effects of the drugs was greater than the sum of the rate-decreasing effects of the individual drugs. These data suggest that the rate-decreasing effects of naloxone and chlorpromazine are synergistic.
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This work was supported in part by grants from U.S. Public Health Service (NB06854) and the Committee on Problems of Drug Dependence, National Academy of Sciences-National Research Council (D-70-6). I wish to thank L. S. Harris and W. L. Dewey for comments on the manuscript. Naloxone was supplied by Endo Laboratories, and chlorpromazine by Smith Kline and French Laboratories.
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McMillan, D.E. Interactions between naloxone and chlorpromazine on behavior under schedule control. Psychopharmacologia 19, 128–133 (1971). https://doi.org/10.1007/BF00402636
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DOI: https://doi.org/10.1007/BF00402636