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Effect of glucose on threshold of intracranial reinforcement

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Abstract

Threshold of reinforcing hypothalamic stimulation in rats was shown to increase as a result of intragastric loading of 10 cm3 of 50% glucose. Thresholds increased steadily up to between 50 and 80 min after glucose injection before they began to decline. Intragastric water loads had no effect on thresholds. To measure thresholds of reinforcement, a new technique was used, which involved a baseline fixed-ratio schedule concurrent with a continuous reinforcement schedule. Increasing and decreasing the magnitude of the continuous reinforcement caused the fixed-ratio postreinforcement pauses to disappear and reappear, providing a method of limits criterion for threshold of reinforcement.

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Author notes

  1. Joseph P. Huston (visiting scientific worker)

    Present address: Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia

Authors and Affiliations

  1. Department of Psychology, Tufts University, Medford, Massachusetts

    Joseph P. Huston (visiting scientific worker)

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  1. Joseph P. Huston
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Additional information

The work reported here was a portion of a PhD dissertation completed at Tufts University, Medford, Mass., and was supported by a NDEA Title IV predoctoral fellowship.

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Huston, J.P. Effect of glucose on threshold of intracranial reinforcement. Psychopharmacologia 19, 105–113 (1971). https://doi.org/10.1007/BF00402634

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  • DOI: https://doi.org/10.1007/BF00402634

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