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The effect of 5-fluorouracil on inhibition of epidermal DNA synthesis in vivo: a comparison of the effect of formulations and a prodrug of 5-FU

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References

  1. Dillaha CJ, Jansen GT, Honeycutt WM, Holt CA (1965) Further studies with topical 5-fluorouracil. Arch Dermatol 92:410–417

    Google Scholar 

  2. Du Vivier A, Stoughton RB (1975) An animal model for screening topical and systemic drugs for potential use in the treatment of psoriasis. J Invest Dermatol 65:235–237

    Google Scholar 

  3. Lowe NJ, Stoughton RB, McCullough JL, Weinstein GD (1981) Topical drug effects on normal and proliferating epidermal cell models. Arch Dermatol 117:394–398

    Google Scholar 

  4. Otani AS, Gange RW, Walter JF (1980) Epidermal DNA synthesis: a new disc technique for evaluating incorporation of tritiated thymidine. J Invest Dermatol 75:375–378

    Google Scholar 

  5. Sherertz EF, Sloan KB, McTiernan RG (1990) Transdermal delivery of 5-fluorouracil through skin of hairless mice and humans in vitro: a comparison of the effect of formulations and a prodrug. Arch Dermatol Res 282:463–468

    Google Scholar 

  6. Sloan KB, Bodor N (1982) Hydroxymethyl and acyloxymethyl prodrugs of theophylline: enhanced delivery of polar drugs through skin. Int J Pharm 12:299–313

    Google Scholar 

  7. Sloan KB, Sherertz EF, McTiernan RG (1988) The effect of structure of Mannich base prodrugs on their ability to deliver theophylline and 5-fluorouracil through hairless mouse skin. Int J Pharm 44:87–96

    Google Scholar 

  8. Stoll HL, Klein E, Case RW (1967) Tumors of the skin. VII. Effect of varying the concentration of locally administered 5-fluorouracil on basal cell carcinoma. J Invest Dermatol 49:219–224

    Google Scholar 

  9. Waranis RP, Sloan KB (1987) Effects of vehicles and prodrug properties and their interactions on the delivery of 6-mercaptopurine through skin: bisacyloxymethyl-6-mercaptopurine prodrugs. J Pharm Sci 76:587–595

    Google Scholar 

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Author notes

  1. E. F. Sherertz

    Present address: Department of Dermatology, Bowman Gray-Wake Forest University, Medical Center, 27103, Winston-Salem, NC, USA

Authors and Affiliations

  1. Department of Medicinal Chemistry, University of Florida, Gainesville, Florida

    K. B. Sloan Ph. D.

  2. Department of Medicine, Veterans Administration Medical Center (Research Service) and University of Florida, Gainesville, Florida

    E. F. Sherertz

  3. Veterans Administration Medical Center (Research Service), Gainesville, Florida, USA

    R. G. McTiernan

Authors
  1. K. B. Sloan Ph. D.
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  2. E. F. Sherertz
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  3. R. G. McTiernan
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Sloan, K.B., Sherertz, E.F. & McTiernan, R.G. The effect of 5-fluorouracil on inhibition of epidermal DNA synthesis in vivo: a comparison of the effect of formulations and a prodrug of 5-FU. Arch Dermatol Res 282, 484–486 (1990). https://doi.org/10.1007/BF00402629

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  • DOI: https://doi.org/10.1007/BF00402629

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