Abstract
The activities of the hepatic glycolytic enzymes glucokinase (GKase) and hexokinase (HKase) in herbivorous Microtus arvalis were very low and the hepatic fructose-1,6-diphosphatase (FDPase) activities were aomost the same as those in C57BL/6J mice. Glycosuria was observed in over 50% of voles fed on a low fibre, high concentrate diet. Voles with a high incidence of glycosuria for over 6 weeks became insulin deficient. In these diabetic voles, the hepatic GKase, HKase and FDPase activities decreased considerably as a result of diminished insulin secretion and fatty degeneration of the hepatic cells. It was considered that M. arvalis would be a useful animal model in which to study disorders of glucose utilization in herbivora.
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Arai, T., Machida, Y., Sasaki, M. et al. Hepatic enzyme activities and plasma insulin concentrations in diabetic herbivorous voles. Vet Res Commun 13, 421–426 (1989). https://doi.org/10.1007/BF00402563
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DOI: https://doi.org/10.1007/BF00402563