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Monoamines and hormone activated oestrous behaviour in the ovariectomized hamster

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Abstract

Oestrous behaviour was activated by oestradiol/progesterone treatment in ovariectomized hamsters. The effects of increased and decreased nervous monoamine levels, achieved by neuropharmacological agents were studied.

Amine depletors reserpine (1–3 mg/kg) and tetrabenazine (40–100 mg/kg) did not reduce the oestrous behaviour while an inhibitory effect was obtained by the monoamine oxidase inhibitor pargyline (150 mg/kg) and nialamide (200 mg/kg). When DOPA or 5-HTP was combined with pargyline the inhibitory effect was enhanced. This was most evident after 5-HTP administration.

The results give evidence of monoamine dependent nervous pathways mediating inhibition of oestrous behaviour in the female hamster.

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Authors and Affiliations

  1. Department of Pharmacology, University of Uppsala, Sweden

    Bengt J. Meyerson

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  1. Bengt J. Meyerson
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Meyerson, B.J. Monoamines and hormone activated oestrous behaviour in the ovariectomized hamster. Psychopharmacologia 18, 50–57 (1970). https://doi.org/10.1007/BF00402383

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  • DOI: https://doi.org/10.1007/BF00402383

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