Abstract
The effect of d-amphetamine in combination with pentobarbital sodium, reserpine, chlorpromazine, meprobamate and chlordiazepoxide has been studied on spontaneous motor activity in male mice. d-Amphetamine together with CNS depressants produced a greater effect than amphetamine alone.
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Babbini, M., Missere, G., Tonini, G.: Imipramine, chlorpromazine and central nervous system stimulants. Acta of the intern meeting on techniques for the study of psychotropic drugs, pp. 88–90. Ed. G. Tonini Modena: Societa Tipografica Modenese 1960.
Borella, L., Herr, F., Wojdan, A.: Prolongation of central effects of amphetamine by chlorpromazine. Canad. J. Physiol. Pharmacol. 47, 7–13 (1969).
Brodie, B. B., Shore, P. A.: A concept for a role of serotonin and norepinephrine or chemical mediator in brain. Ann. N. Y. Acad. Sci. 66, 631–642 (1957).
— —, Platscher, A.: Serotonin releasing activity limited to Rauwolfia alkaloid with tranquillising action. Science 123, 992–993 (1956).
Goldstein, A., Aronow, L., Kalman, S. M.: Drug metabolism. In: Principle of drug action. (The basis of Pharmacology), pp. 206–279. New York: Harper & Row, Publ. 1968.
Haggendal, J., Lindqvist, M.: Brain monoamine levels and behaviour during long term administration of reserpine. Int. J. Neuropharmacol. 3, 59–64 (1964).
Miller, N. E.: Some recent studies of conflict behaviour and drugs. Amer. Psychologist 16, 12–24 (1961).
—: The analysis of motivational effects illustrated by experiments on amylobarbitone sodium. CIBA foundation symposium on animal behaviour and drug action, pp. 1–17. London: Churchill 1963.
Pirch, J. H., Rech, R. H.: Behavioral recovery in rats during chronic reserpine treatment. Psychopharmacologia (Berl.) 12, 115–122 (1968).
Quinton, R. M., Halliwell, G.: Effects of α-methyl dopa and DOPA on the amphetamine excitatory response in reserpinized rats. Nature (Lond.) 200, 178–179 (1963).
Rech, R. H.: α-Methyltyrosine (αMT) interaction with d-amphetamine (dA) and other stimulants in rat Sidman avoidance behaviour. Fed. Proc. 27, 274 (1968).
Ruston, R., Steinberg, H.: Mutual potentiation of amphetamine and amylobarbiturate measured by activity in rats. Brit. J. Pharmacol. 21, 295–305 (1963).
Sethy, V. H., Sheth, U. K.: Pharmacology of 2-aminoethyl-3-phenyl norcamphane hydrochloride. Part I-Action on central nervous system. Indian. J. med. Sci. 22, 603–615 (1968).
Sharpless, S. K.: Reorganisation of function in the nervous system. Uses and disuses. Ann. Rev. Physiol. 26, 357–388 (1964).
Smith, C. B.: Enhancement by reserpine and α-methyl DOPA of the effects of d-amphetamine upon the locomotor activity of mice. J. Pharmacol. exp. Ther. 142, 343–350 (1963).
—: Effect of d-amphetamine upon brain amin content and locomotor activity of mice. J. Pharmacol. exp. Ther. 147, 96–102 (1965).
Stein, L.: New methods for evaluating stimulants and antidepressants. In: Psychosomatic medicine, pp. 297–311. Eds.: J. H. Nodine and J. H. Moyer. Philadelphia: Lea & Febinger 1962.
Stolk, J. M., Rech, R. H.: Enhanced stimulant effect of d-amphetamine on the spontaneous locomotor activity of rats treated with reserpine. J. Pharmacol. exp. Ther. 158, 140–149 (1967).
Sulser, F., Dingell, J. V.: Potentiation and blockade on central action of amphetamine by chlorpromazine. Biochem. Pharmacol. 17, 634–636 (1968).
Trendelen, U.: Supersensitivity and subsensitivity to sympathomimetic amines. Pharmacol. Rev. 15, 225–277 (1963).
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Sethy, V.H., Naik, P.Y. & Sheth, U.K. Effect of d-amphetamine sulphate in combination with CNS depressants on spontaneous motor activity of mice. Psychopharmacologia 18, 19–25 (1970). https://doi.org/10.1007/BF00402380
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DOI: https://doi.org/10.1007/BF00402380