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Alpha-1-antitrypsin phenotypes in a group of newborn infants in Somalia

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Summary

Pi phenotype determinations were performed on umbilical cord serum specimens of 347 infants born in Mogadishu (Somalia) hospitals. Phenotyping was performed by isoelectric focusing on polyacrylamide gel slabs. Sera containing α 1AT in types other than MM were also studied by crossed antigen-antibody immunoelectrophoresis on agar.

The most frequently occuring Pi allele proved to be PiM. With respect to the other African populations studied so far, there was a high prevalence of the PiS and PiZ alleles. In particular, three individuals were found with the ZZ phenotype, which had not yet been observed in Africa.

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Abbreviations

α 1AT:

(human serum) alpha-1-antitrypsin

Pi :

protease inhibitor

References

  • Allen, R. C., Harley, R. A., Talamo, R. C.: A new method for determination of alpha-1-antitrypsin using isoelectric-focusing on polyacrylamide gel slabs. Amer. J. clin. Path. 62, 732–739 (1974)

    Google Scholar 

  • Blundell, G., Frazer, A., Cole, R. B., Nevin, N. C.: Alpha-1-antitrypsin phenotypes in Northern Ireland. Ann. hum. Genet. 38, 389–294 (1975)

    Google Scholar 

  • Fagerhol, M. K.: Acid starch gel electrophoresis for detection of α 1-antitrypsin variants (Pi types): outline of techniques employed currently. In: Pulmonary emphysema and proteolysis, C. Mittman, ed., New York: Academic 1972

    Google Scholar 

  • Fagerhol, M. K., Tenfjord, O. W.: Serum Pi types in some European, American, Asian and African populations. Acta path. Microbiol. scand. 72, 601–608 (1968)

    PubMed  Google Scholar 

  • Fagerhol, M. K., Eriksson, A. W., Monn, E.: Serum Pi types in some Lappish and Finnish populations. Hum. Hered. 19, 360–364 (1969)

    PubMed  Google Scholar 

  • Goedde, H. W., Hirth, L., Beukmann, H. G., Pellicer, A., Pellicer, T., Stahn, M., Singh, S.: Population genetic studies of serum protein polymorphisms in four Spanish populations. Hum. Hered. 23, 135–146 (1973)

    PubMed  Google Scholar 

  • Kellermann, G., Walter, H.: Investigation on the population genetics of the α 1-antitrypsin polymorphism. Humangenetik 10, 145–150 (1970)

    Google Scholar 

  • Kueppers F.: Determination of α 1-antitrypsin phenotypes by isoelectric focusing in polyacrylamide gels. J. Lab. clin. Med. 88, 151–155 (1976)

    PubMed  Google Scholar 

  • Mukherjee, B. N., Das S. K., Kellermann, G.: Study of some serum group systems in the Mahishyes and the Muslims in 24-Parganas District, West Bengal. Humangenetik 21, 27–32 (1974)

    PubMed  Google Scholar 

  • Musiani, P., Tomasi, T. B.: Isolation, chemical and physical properties of α 1-antitrypsin. Biochemistry 15, 798–804 (1975)

    Google Scholar 

  • Pierce, J. A., Bibiana E., Dew, A. T.: Antitrypsin phenotypes in St. Louis. J. Amer. med. Ass. 231 609–612 (1975)

    Article  Google Scholar 

  • Pierce, J. A., Jeppsson, J. O., Laurell, C. B.: α 1-globulin phenotypes determined by isoelectric of α 1-antitrypsin mixed disulfide in serum. Anal. Biochem. 74, 227–241 (1976)

    PubMed  Google Scholar 

  • Talamo, R. C., Thurlbeck, W. M.: Alpha-1-antitrypsin Pi types in postmortem blood. Amer. Rev. res. Dis. 112, 201–207 (1975)

    Google Scholar 

  • Vandeville, D., Martin, J. P., Ropartz, C.: α 1-antitrypsin polymorphism of a Bantu population: Description of a new allele PiL. Humangenetik 21, 33–38 (1974)

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Istituto di Anatomia e Istologia Patologica, Università Cattolica del Sacro Cuore, via Pineta Sacchetti 644, I-00168, Roma, Italy

    Guido Massi & Fabio M. Vecchio

Authors
  1. Guido Massi
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  2. Fabio M. Vecchio
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Massi, G., Vecchio, F.M. Alpha-1-antitrypsin phenotypes in a group of newborn infants in Somalia. Hum. Genet. 38, 265–269 (1977). https://doi.org/10.1007/BF00402151

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