, Volume 17, Issue 3, pp 242–257 | Cite as

The action of tryptamine on the dog spinal cord and its relationship to the agonistic actions of LSD-like psychotogens

  • W. R. Martin
  • C. G. Eades
Original Investigations


In chronic spinal dogs, LSD, mescaline, psilocin, 2,5-dimethoxy-4-methylamphetamine, methysergide and tryptamine facilitate the flexor reflex evoked by tetanic electrical stimulation of the toe and induce the stepping reflex. These effects are antagonized by chlorpromazine and cyproheptadine, but not by phenoxybenzamine. 5-Hydroxytryptophan and serotonin also facilitate the flexor reflex and evoke the stepping reflex, but these effects are not antagonized by cyproheptadine. These findings suggest that the mode of action of several LSD-like psychotogens is similar to that of tryptamine and is different from that of serotonin or 5-hydroxytryptophan.


Tryptamine LSD Psychotogens Chlorpromazine Spinal Cord 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Banna, N. R., Anderson, E. G.: The effects of 5-hydroxytryptamine antagonists on spinal neuronal activity. J. Pharmacol. exp. Ther. 162, 319–325 (1968).Google Scholar
  2. Geiger, L. E., Cervoni, P.: Effect of D-lysergic acid diethylamide on spinal reflexes. Proc. Soc. exp. Biol. (N.Y.) 99, 179–181 (1958).Google Scholar
  3. Handschumacher, R. E., Vane, J. R.: The relationship between the penetration of tryptamine and 5-hydroxytryptamine into smooth muscle and the associated contractions. Brit. J. Pharmacol. 29, 105–118 (1967).Google Scholar
  4. Krivoy, W. A.: Potentiation of substance P by lysergic acid diethylamide in vivo. Brit. J. Pharmacol. 16, 253–256 (1961).Google Scholar
  5. Marley, E., Vane, J. R.: Tryptamines and spinal cord reflexes in cats. Brit. J. Pharmacol. 31, 447–465 (1967).Google Scholar
  6. Martin, W. R., Eades, C. G.: Pharmacological studies of spinal cord adrenergic and cholinergic mechanisms and their relation to physical dependence on morphine. Psychopharmacologia (Berl.) 11, 195–223 (1967).Google Scholar
  7. — —: Interactions between norepinephrine antagonists and potentiators (chlorpromazine, chlorpromazine sulfoxide and imipramine) and sympathetic amines (amphetamine and methoxamine) on the flexor reflex of the chronic spinal dog. Int. J. Neuropharmacol. 7, 493–501 (1968).Google Scholar
  8. Shibuya, T., Anderson, E. G.: The influence of chronic cord transection on the effects of 5-hydroxytryptophan, L-tryptophan and pargyline on spinal neuronal activity. J. Pharmacol. exp. Ther. 164, 185–190 (1968).Google Scholar
  9. Slater, I. H., Davis, K. H., Leary, D. E., Boyd, E. S.: The action of serotonin and lysergic acid diethylamide on spinal reflexes. J. Pharmacol. exp. Ther. 113, 48–49 (1955).Google Scholar
  10. Snedecor, G. W.: Statistical methods, 5th ed. Ames: Iowa State College Press 1956.Google Scholar
  11. Weidmann, H., Cerletti, A.: Die Wirkung von D-lysergsaure-diathylamid und 5-hydroxytryptamin (Serotonin) auf spinale Reflexe der Katze. Helv. physiol. pharmacol. Acta 15, 376–383 (1957).Google Scholar
  12. — —: Studies on psilocybin and related compounds. Helv. physiol. pharmacol. Acta 18, 174–182 (1960).Google Scholar
  13. Wikler, A., Frank, K.: Hindlimb reflexes of chronic spinal dogs during cycles of addiction to morphine and methadon. J. Pharmacol. exp. Ther. 94, 382–400 (1948).Google Scholar

Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • W. R. Martin
    • 1
    • 2
  • C. G. Eades
    • 1
    • 2
  1. 1.Addiction Research CenterNational Institute of Mental HealthLexingtonUSA
  2. 2.U.S.Department of Health, Education and WelfarePublic Health Service Health Services and Mental Health AdministrationUSA

Personalised recommendations