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Hemopoietic stem cells and target cells in murine-virus-induced leukemias

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References

  • Axelrad AA, Suzuki S, van der Gaag H, Clarke BJ, McLeod DL (1978) Friend virus and malignant erythropoiesis, a genetic analysis. In: Golde D, Cline M (ed) Hematopoietic cell diferentiation. Academic Press, New York, pp 69–90

    Google Scholar 

  • Baltimore D, Rosenberg N, Witte ON (1979) Transformation of immature lymphoid cells by Abelson murine leukemia virus. Immunol Rev 48:3–22

    PubMed  Google Scholar 

  • Bird AG, Britton S (1979) A live human B-cell activator operating in isolation of other cellular influences. Scand J Immunol 9:507–510

    PubMed  Google Scholar 

  • Boiron M, Leevy JP, Lasneret J, Oppenheim S, Bernard J (1965) Pathogenesis of Rauscher leukemia. J Natl Cancer Inst 35:865–884

    PubMed  Google Scholar 

  • Boniver J, Simar LJ, Courtoy R, Betz EH (1978) Quantitative analysis of thymus lymphoid cells during murine leukemogenesis. Cancer Res 38:52–58

    PubMed  Google Scholar 

  • Boniver J, Decléve A, Liebermann M, Honsik C, Travis M, Kaplan H (1981) Marrow-thymus interactions during radiation-leukemogenesis in C57/Bl/Ka mice. Cancer Res 41:390–392

    PubMed  Google Scholar 

  • Boss M, Greaves M, Teich N (1979) Abelson virus-induced haematopoietic cell lines with pre-B-cell characteristics. Nature 278:551–553

    PubMed  Google Scholar 

  • Chazan R, Haran-Ghera N (1976) The role of thymus subpopulations in “T” leukemia development. Cell Immunol 23:356–375

    PubMed  Google Scholar 

  • Chevalier C, Gaillard N, Frindel E (1974) The number of in vitro stem cells in AKR leukemic mice. Blood 44:743–750

    PubMed  Google Scholar 

  • Cooper MD, Kearney JG, Lydyard DM, Grossi CE, Lawton AR (1976) Studies of generation of B-cell diversity in mouse, man and chicken. Cold Spring Harbor Symp Quant Biol 41:139–145

    Google Scholar 

  • Covelli V, Di Majo V, Bassani B, Metalli P, Silini G (1981) Failure to detect preleukemic cells in BC3F1 mice during the latent period of thymic lymphoma induction. Leukemia Res 5:176–177

    Article  Google Scholar 

  • Dexter TM, Testa NG (1976) Differentiation and proliferation of hemopoietic cells in culture. Methods Cell Biol 14:387–405

    PubMed  Google Scholar 

  • Dexter TM, Scott D, Teich NM (1977) Infection of bone marrow cells in vitro with FLV: effects on stem cell proliferation, differentiation and leukemogenic capacity. Cell 2:355–364

    Article  Google Scholar 

  • Dexter TM, Allen TD, Scott D, Teich NM (1979) Isolation and characterization of a bipotential haematopoietic cell line. Nature 277:471–474

    PubMed  Google Scholar 

  • Dexter TM, Allen TD, Testa NG, Scolnick (1981a) Friend disease in vitro. J Exp Med 154: 594–608

    PubMed  Google Scholar 

  • Dexter TM, Testa NG, Allen TD, Rutherford T, Scolnick E (1981b) Molecular and cell biologic aspects of erythropoiesis in long-term bone marrow cultures. Blood 58:699–707

    PubMed  Google Scholar 

  • Eliason JF, Testa NG, Dexter TM (1979) Erythropoietin-stimulated erythropoiesis in long-term bone marrow culture. Nature 281:382–384

    PubMed  Google Scholar 

  • Fey F (1969) Die Bedeutung der Milz in der Pathogenese muriner virusinduzierter Leukämien. 2 Inn Med 24:511–513

    Google Scholar 

  • Friend C (1957) Cell-free transmission in adult mice of a disease having the character of a leukemia. J Exp Med 105:307–318

    PubMed  Google Scholar 

  • Frindel E, Chevalier C (1975) Measurement of the number of bone marrow multipotential stem cells in AKR leukaemic mice. Biomedicine 23:166–167

    PubMed  Google Scholar 

  • Golde DW, Faille A, Sullivan A, Friend C (1976) Granulocytic stem cells in Friend leukemia. Cancer Res 36:115–119

    PubMed  Google Scholar 

  • Graffi A (1957) Chloroleukemia of mice. Ann NY Acad Sci 68:540–558

    PubMed  Google Scholar 

  • Graffi A, Bielka H, Fey F, Scharsach F, Weiss R (1954) Gehäuftes Auftreten von Leukämien nach Injektion von Sarkom-Filtraten. Naturwissenschaften 41:503–504

    Google Scholar 

  • Greenberger JS (1979) Phenotypically distinct target cells for murine sarcoma virus and murine leukemia virus marrow transformation in vitro. J Natl Cancer Inst 62:337–348

    PubMed  Google Scholar 

  • Greenberger JS, Stephenson JR, Moloney WC, Aaronson SA (1975) Different hematologic diseases induced by type C viruses chemically activated from embryo cells of different mouse strains. Cancer Res 35:245–252

    PubMed  Google Scholar 

  • Greenberger JS, Davisson PB, Gans PJ, Moloney WC (1979) In vitro induction of continuous acute promyelocytic leukemia cell lines by Friend or Abelson murine leukemia virus. Blood 53:987–1001

    PubMed  Google Scholar 

  • Greenberger JS, Newburger PE, Lipton JM, Moloney WC, Sakakeeney M, Jackson PL (1980a) Virus and cell requirements for Friend virus granulocytic leukemogenesis in long-term bone marrow cultures of NIH [N: NIH(S)] mice. J Natl Cancer Inst 64:867–878

    PubMed  Google Scholar 

  • Greenberger JS, Eckner RJ, Ostertag W, Colletta G, Boschetti S, Nagasawa H, Kaspas A, Wichselbaum RR, Moloney WC (1980b) Release of spleen focus forming virus (SFFV) from differentiation inducible promyelocytic leukemia cell lines transformed in vitro by Friend leukemia virus. Virology 105:425–435

    Article  PubMed  Google Scholar 

  • Gross L (1970) Mouse leukemia. In: Gross L (ed) Oncogenic viruses. Pergamon Press, Oxford, pp 286–358

    Google Scholar 

  • Hankins WD, Kost RA, Koury MJ, Krantz SB (1978) Erythroid bursts produced by Friend leukaemia virus in vitro. Nature 276:506–508

    PubMed  Google Scholar 

  • Hankins WD, Kost TA, Koury MJ, Krantz SB (1979) An in vitro system for erythroid transformation by Friend leukemia virus. In: Baum SJ, Ledney ED (eds) Experimental hematology today. Springer, New York, pp 89–98

    Google Scholar 

  • Hankins WD, Troxler D (1980) Polycythemia- and anemia-inducing erythroleukemia viruses exhibit differential erythroid transforming effects in vitro. Cell 22:693–699

    PubMed  Google Scholar 

  • Haot J, Betz EH, Revesz L (1973) Characterization of a new lymphoid cell type detected in the irradiated mouse. Nature (New Biol) 244:211–212

    Google Scholar 

  • Haran-Ghera N, Liebermann M, Kaplan HS (1966) Direct action of a leukemogenic virus on the thymus. Cancer Res 26:438–441

    PubMed  Google Scholar 

  • Haran-Ghera N, Peled A (1973) Thymus and bone marrow derived lymphatic leukaemia in mice. Nature 241:396–398

    PubMed  Google Scholar 

  • Haran-Ghera N, Peled A (1979) Induction of leukemia in mice by irradiation and radiation leukemia virus variants. Adv Cancer Res 30:45–87

    PubMed  Google Scholar 

  • Haran-Ghera N, Rubio N, Leef F, Goldstein G (1978) Characteristics of preleukemia cells induced in mice. Cell Immunol 37:308–314

    PubMed  Google Scholar 

  • Hasthorpe S, Bol S (1979) Erythropoietin responses and physical characterization of erythroid progenitor cells in Rauscher virus infected Balb/c mice. J Cell Physiol 100:77–86

    PubMed  Google Scholar 

  • Hays EF, Craddock CG, Haskett D, Newell M (1976) In vitro colony-forming cells in the marrow of leukemic and preleukemic mice. Blood 47:603–610

    PubMed  Google Scholar 

  • Hays EF, Haskett DR, Kaspersky CJ, Craddock CG (1978) Alterations in bone marrow and thymus lymphocytes in virus-inoculated, inbred, preleukemic AKR mice. J Natl Cancer Inst 60:905–909

    PubMed  Google Scholar 

  • Horoszewicz JS, Leong SSS, Carter WA (1975) Friend leukemia: rapid development of erythropoietin-independent hematopoietic precursors. J Natl Cancer Inst 54:265–267

    PubMed  Google Scholar 

  • Kaplan HS (1974) Leukemia and lymphoma in experimental and domestic animals. Ser Haematol 7:94–163

    PubMed  Google Scholar 

  • Kaplan HS, Liebermann M (1976) The role of lymphoid and haemopoietic target cells in viral lymphomagenesis of C57/Bl/Ka mice. II. Neoplastic transformation of bone marrow-derived cells in the thymic microenvironment. Blood Cells 2:301–317

    Google Scholar 

  • Kost TA, Koury MJ, Hankins WD, Krantz SB (1979) Target cells for Friend virus-induced erythroid bursts in vitro. Cell 18:145–152

    PubMed  Google Scholar 

  • Kost TA, Koury MJ, Krantz SB (1981) Mature erythroid burst-forming units are target cells for Friend virus-induced erythroid bursts. Virology 108:309–317

    PubMed  Google Scholar 

  • Koury MJ, Kost TA, Hankins WD, Krantz SB (1979) Response of erythroid day 3 burst-forming units to endotoxin and erythropoietin. Proc Soc Exp Biol Med 162:275–280

    PubMed  Google Scholar 

  • Kreja L, Seidel HJ (1981) BFU-E growth after Friend virus infection in vivo. Exp Hematol 9 (Suppl. 9); 179

    PubMed  Google Scholar 

  • Legrand E, Daculsi R, Duplan JF (1981) Respective inhibitory action of bone marrow and spleen CFU's on radiation-induced leukaemogenesis in C57/Bl mice. Leukemia Res 5:173–178

    Google Scholar 

  • Legrand E, Kressmann MC, Duplan JF (1975) Leucemogénèse et régénération du système lymphoid chez des hybrides F1 (C3H x AKR/TlALD) restaurés par des cellules médullaires et thymiques parentales. Int J Cancer 15:572–587

    PubMed  Google Scholar 

  • Liao SK, Axelrad AA (1975) Erythropoietin-independent erythroid colony formation in vitro by hemopoietic cells of mice infected with Friend virus. Int J Cancer 15:467–482

    PubMed  Google Scholar 

  • Liebermann M, Kaplan HS (1976) The role of lymphoid and haemopoietic target cells in viral lymphomagenesis of C57/Bl/Ka mice. I. Susceptibility to viral replication. Blood Cells 2:291–299

    Google Scholar 

  • Lilly F, Pincus T (1973) Genetic control of murine viral leukemogenesis. Adv Cancer Res 17:231–277

    Google Scholar 

  • MacDonald ME, Mak TW, Bernstein A (1980a) Erythroleukemia induction by replication-competent type C viruses cloned from the anemia- and polycythemia-inducing isolates of Friend leukemia virus. J Exp Med 151:1493–1503

    PubMed  Google Scholar 

  • MacDonald ME, Reynolds FH, Van de Ven WJM, Stephenson JR, Mak TW, Bernstein A (1980b) Anemia- and polycythemia inducing isolates of Friend spleen focus-forming virus. Biological and molecular evidence for two distinct virus genomes. J Exp Med 151:1477–1492

    PubMed  Google Scholar 

  • Mager DL, Mak TW, Bernstein A (1981) Quantitative colony method for tumorigenic cells transformed by two distinct strains of Friend leukemia virus. Proc Natl Acad Sci USA 78:1703–1707

    PubMed  Google Scholar 

  • Maisin JR, Leonard A, Mattelin G (1980) Preleukemic cells and radiation-induced thymoma. Biomedicine 33:47–49

    PubMed  Google Scholar 

  • McGarry MP, Steeves RA, Eckner RJ, Mirand EA, Trudel PJ (1974) Isolation of a myelogenous leukemia-inducing virus from mice infected with the Friend virus complex. Int J Cancer 13:867–878

    PubMed  Google Scholar 

  • Mirand EA (1967) Virus-induced erythropoiesis in hypertransfused polycythemic mice. Science 156:832–833

    PubMed  Google Scholar 

  • Mirand EA (1976) Autonomous erythropoiesis induced by a virus. Semin Hematol 13:49–56

    PubMed  Google Scholar 

  • Okunewick JP (1977) The role of committed and uncommitted hematopoietic stem cells as targets for Rauscher and Friend leukemia viruses. Biomedicine 26:152–157

    PubMed  Google Scholar 

  • Okunewick JP, Phillips EL, Brozovich BJ (1974) Antiserum inactivation of hematopoietic colony-forming stem cells from mice with Rauscher leukemia. Experientia 30:1470–1471

    PubMed  Google Scholar 

  • Opitz U, Seidel HJ, Rich I (1977) Erythroid stem cells in Rauscher virus infected mice. Blut 35: 35–44

    PubMed  Google Scholar 

  • Opitz U, Seidel HJ (1978) Studies on the target cell for the Friend virus (Fv-P strain) using the CFU-E technique. Blut 37:183–192

    PubMed  Google Scholar 

  • Opitz U, Seidel HJ, Bertoncello I (1978) Erythroid stem cells in Friend virus infected mice. J Cell Physiol 96:95–104

    PubMed  Google Scholar 

  • Owen JJT, Wright DE, Habu S, Raff MC, Cooper MD (1978) Studies on the generation of B-Lymphocytes in fetal liver and bone marrow. J Immunol 118:2067–2072

    Google Scholar 

  • Pazmino NH, McEwan RN, Ihle JN (1977) Distribution of terminal deoxynucleotidyl transferase in bovine serum albumin gradient-fractionated thymocytes and bone marrow cells of normal and leukemic mice. J Immunol 119:494–499

    PubMed  Google Scholar 

  • Pazmino NH, McEwan RN, Ihle JN (1978) Radiation leukemia in C57/Bl/6 mice. III. Correlation of altered expression of terminal deoxynucleotidyl transferase to induction of leukemia. J Exp Med 148:1338–1350

    PubMed  Google Scholar 

  • Peschle C, Migliaccio G, Lettieri F, Migliaccio AR, Ceccarelli R, Barba P, Titti F, Rossi GB (1980) Kinetics of erythroid precursors in mice infected with the anemic or the polycythemic strain of Friend leukemia virus. Proc Natl Acad Sci USA 77:2054–2058

    PubMed  Google Scholar 

  • Potter M, Premkumar-Reddy E, Wivel NA (1978) Immunoglobulin production by lymphosarcomas induced by Abelson virus in mice. Natl Cancer Inst Monogr 48:311–320

    PubMed  Google Scholar 

  • Premkumar E, Potter M, Singer PA, Sklar MD (1975) Synthesis, surface deposition, and secretion of immunoglobulins by Abelson virus-transformed lymphosarcoma cell lines. Cell 6:149–159

    PubMed  Google Scholar 

  • Rauscher FJ (1962) A virus-induced disease of mice characterized by erythropoiesis and lymphoid leukemia. J Natl Cancer Inst 29:515–543

    PubMed  Google Scholar 

  • Reisner Y, Sharon N, Haran-Ghera N (1980) Expression of peanut agglutinin receptors on virus-induced preleukemic cells in mice. Proc Natl Acad Sci USA 77:2244–2246

    PubMed  Google Scholar 

  • Risser R (1979) Abelson antigen is expressed on hematopoietic spleen colony-forming cells from mice carrying the AV-2S virus sensitivity gene. Proc Natl Acad Sci USA 76:5350–5354

    PubMed  Google Scholar 

  • Risser R, Stockert E, Old LJ (1978) Abelson antgen: a viral tumor antigen that is also a differentiation antigen of Balb/c mice. Proc Natl Acad Sci USA 75:3918–3922

    PubMed  Google Scholar 

  • Rosenberg N, Baltimore D (1976) A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med 143:1453–1463

    PubMed  Google Scholar 

  • Rosenberg N, Baltimore D (1980) Abelson virus. In: Klein G (ed) Viral Oncology. Raven Press, New York, pp 178–203

    Google Scholar 

  • Sainteny F, Frindel E (1979) AKR leukemogenesis and the hemopoietic stem cell compartment. Exp Hematol 7 [Suppl 6] 71

    Google Scholar 

  • Seidel HJ, Opitz U (1978) Comparative studies on hemopoietic stem cell pools in mice after Friend (FVP) or Rauscher infection. In: Murphy MJ Jr (ed) In vitro aspects of erythropoiesis. Springer, Berlin Heidelberg New York, pp 143–148

    Google Scholar 

  • Shinefeld LA, Sato VL, Rosenberg N (1980) Monoclonal rat-antimouse brain antibody detects Abelson murine leukemia virus target cells in mouse bone marrow. Cell 20:11–17

    PubMed  Google Scholar 

  • Siden EJ, Baltimore D, Clark D, Rosenberg NE (1979) Immunoglobin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus. Cell 16:389–396

    PubMed  Google Scholar 

  • Siegler R, Rich MA (1967) Pathogenesis of virus-induced myeloid leukemia in mice. J Natl Cancer Inst 38:31–50

    PubMed  Google Scholar 

  • Silverstone AE, Cantor H, Goldstein G, Baltimore D (1976) Terminal deoxynucleotidyl transferase is found in prothymocytes. J Exp Med 144:543–548

    PubMed  Google Scholar 

  • Soule HD, Arnold WJ (1970) Murine myeloproliferative virus in cell culture. J Natl Cancer Inst 45:253–262

    PubMed  Google Scholar 

  • Steeves RA (1975) Spleen focus-forming virus in Friend and Rauscher leukemia virus preparation. J Natl Cancer Inst 54:289–297

    PubMed  Google Scholar 

  • Steeves RA, Bubbers JE, Plata F, Lilly F (1978) Origin of spleen colonies generated by Friend virusinfected cells in mice. Cancer Res 38:2729–2733

    PubMed  Google Scholar 

  • Steinheider G, Steeves R (1978) A target cell assay for Friend virus. Leukemia Res 2:197–200

    Google Scholar 

  • Steinheider G, Seidel HJ, Kreja L (1979) Characterization of a Friend virus-replicating target cell. Exp Hematol 7:443–451

    PubMed  Google Scholar 

  • Suzuki S, Axelrad AA (1980) Fv-2 locus controls the proportion of erythropoietic cells (BFU-E) synthesizing DNA in normal mice. Cell 19:225–236

    PubMed  Google Scholar 

  • Tambourin PE (1976) Haemopoietic stem cells and murine viral leukaemogenesis. In: Lord BI, Potten CS, Cole RJ (eds) Stem cells and tissue homeostasis. Cambridge University Press, Cambridge, pp 259–316

    Google Scholar 

  • Tambourin PE, Wendling F (1975) Target cell for oncogenic action of polycythaemia-inducing Friend virus. Nature 256:320–322

    PubMed  Google Scholar 

  • Tambourin PE, Wendling F, Jasmin C, Smadja-Joffe F (1979) The physiopathology of Friend leukemia. Leukemia Res 3:117–129

    Google Scholar 

  • Teich NM, Dexter TM (1979) Effects of murine leukemia virus infection on differentiation of hematopoietic cells in vitro. In: Clarkson B, Marks PA, Till JE (eds) Differentiation of normal and noeplastic cells. Cold Spring Harbor Conferences on Cell Proliferation, Vol 5. Cold Spring Harbor, pp 657–670

  • Testa NG, Dexter TM, Scott D, Teich NM (1980) Malignant myelomonocytic cells after in vitro infection of marrow cells with Friend leukemia virus. Br J Cancer 41:33–39

    PubMed  Google Scholar 

  • Testa NG, Dexter TM (1977) Long-term production of erythroid precursor cells (BFU) in bone marrow culture. Cifferentiation 9:193–195

    Google Scholar 

  • Thomson S, Axelrad AA (1968) A quantitative spleen colony assay method for tumor cells induced by Friend leukemia virus infection in mice. Cancer Res 28:2105–2114

    Google Scholar 

  • Troxler DH, Ruscetti SK, Scolnick EM 1980) The molecular biology of Friend virus. Biochim Biophys Acta 605:305–324

    PubMed  Google Scholar 

  • Van Bekkum DW, Knaan S, Boersma WJA (1981) The role of haemopoietic stem cells in radiation induced leukaemogenesis. Leukemia Res 5:175

    Google Scholar 

  • Weimann BJ (1976) Induction of immunglobulin synthesis in Abelson murine leukemia virus-transformed mouse lymphoma cells in culture. Cold Spring Harbor Symp Quant Biol 41:163–164

    Google Scholar 

  • Wendling F, Tambourin PE (1978) Oncogenicity of Friend virus-infected cells: Determination of origin of spleen colonies by the H-2 antigens as genetic markers. Int J Cancer 22:479–486

    PubMed  Google Scholar 

  • Wendling F, Moreau-Gachelin F, Tambourin PE (1981) Emergence of tumorigenic cells during the course of Friend virus leukemias. Proc Natl Acad Sci USA 78:3614–3618

    PubMed  Google Scholar 

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  1. Department of Clinical Physiology and Occupational Medicine, University of Ulm, D-7900, Ulm/Donau, Germany

    H. J. Seidel

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The “Journal of Cancer Research and Clinical Oncology” publishes in loose succession “Editorials” and “Guest Editorials” on current and/or controversial problems in experimental and clinical oncology. These contributions represents exclusively the personal opinion of the author. The Editors

This work has been supported by the Deutsche Forschungsgemeinschaft (SFB 112) and the Volkswagenwerk-Stiftung

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Seidel, H.J. Hemopoietic stem cells and target cells in murine-virus-induced leukemias. J Cancer Res Clin Oncol 104, 1–12 (1982). https://doi.org/10.1007/BF00402048

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