Abstract
Three dosage levels of barbiturate and three of amphetamine were compared with a placebo, all under three set conditions (neutral, stimulant and sedative). Drug reactions were assessed by performance measures and by self-rating scales administered at a series of standard times following the drug administration in order to provide drug-time-response patterns.
The self-rating scales yielded clear dosage-time-response curves for both drugs at all dosage levels. There was no systematic evidence of set or drug-by-set-effects. Research strategies in human drug studies are discussed.
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Agnew, N.M., Ernest, C.H. Dose-response and biased set study of an amphetamine and a barbiturate. Psychopharmacologia 19, 282–296 (1971). https://doi.org/10.1007/BF00401945
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DOI: https://doi.org/10.1007/BF00401945