Abstract
Strychnine sulphate administered to rats during development from day 51 to day 70 affected the rate of maze learning in adulthood. Rats given the drug in a rich environment learned the maze at a faster rate and with fewer errors than rats treated with the same drug but raised in small laboratory cages. The performance of rats given no drug was intermediate to that of the drug-rich and drug-caged groups.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Breen, R. A., McGaugh, J. L.: Facilitation of maze learning with posttrial injections of picrotocin. J. comp. physiol. Psychol. 54, 498–501 (1961).
Krech, D., Rosenzweig, M. R., Bennett, E. L.: Effects of environmental complexity and training on brain chemistry. J. comp. physiol. Psychol. 53, 509–519 (1960).
LeBoeuf, B. J., Peeke, H. V. S.: The effect of strychnine administration during development on adult maze learning in the rat. Psychopharmacologia (Berl.) 16, 49–53 (1969).
McGaugh, J. L., Petrinovich, L.: The effect of strychnine sulphate on maze learning. Amer. J. Psychol. 72, 99–102 (1959).
Petrinovich, L. R., Bradford, D., McGaugh, J. L.: Drug facilitation of memory in rats. Psychon. Sci. 2, 191–192 (1965).
Author information
Authors and Affiliations
Additional information
This research was supported in part by General Research Support Grant FR 05550 from N. I. M. H. to Langley Porter Neuropsychiatric Institute, and in part by Mental Health Training Grant 5-TI-MH-7082-07 to the University of California at San Francisco.
Rights and permissions
About this article
Cite this article
Peeke, H.V.S., LeBoeuf, B.J. & Herz, M.J. The effect of strychnine administration during development on adult maze learning in the rat II: Drug administration from day 51 to 70. Psychopharmacologia 19, 262–265 (1971). https://doi.org/10.1007/BF00401942
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00401942