Summary
Rats were trained to discriminate response produced cues in one component of a multiple schedule and the onset of a clicker in the other component. The response requirements were identical. Scopolamine intoxication resulted in a deterioration of the interoceptive cue discrimination and an improvement in the discrimination of the exteroceptive stimuli.
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Anger, D.: The dependence of inter-response times upon the relative reinforcement of different inter-response times. J. exp. Psychol. 52, 141–161 (1956).
- The role of temporal discriminations in the reinforcement of Sidman avoidance behavior. J. exp. Anal. Behav. 6, Supplement 1 (1963).
Berryman, B., W. Wagman, and F. S. Keller: Chlorpromazine and the discrimination of response produced cues. pp. 243–249. In: L. Uhr and J. G. Miller (Eds.) Drugs and Behavior. New York: Wiley 1960.
Boren, J. J., and A. P. Navarro: The action of atropine, benactyzine and scopolamine upon fixed interval and fixed ratio behavior. J. exp. Anal. Behav. 2, 107–116 (1955).
Carlton, P. L.: Cholinergic mechanisms in the control of behavior by the brain. Psychol. Rev. 70, 19–39 (1963).
- Brain—Acetylcholine and Habituation. In: Bradley, P. B., and M. Fink (Eds.). Progress in Brain Research. Amsterdam: Elsevier (in press).
Dews, P. B.: Studies on behavior: II. The effects of pentobarbital methamphetamine and scopolamine on performances in pigeons involving discriminations. J. Pharmacol. exp. Ther. 115, 380–389 (1955).
—: Studies on behavior: III. Effects of scopolamine on reversal of a discriminatory performance in pigeons. J. Pharmacol. exp. Ther. 119, 343–353 (1957).
Hearst, E.: Effects of scopolamine on discriminated responding in the rat. J. Pharmacol. exp. Ther. 126, 349–358 (1959).
Herrnstein, R. J.: Effects of scopolamine on a multiple schedule. J. exp. Anal. Behav. 1, 351–358 (1958).
Laties, V. G., and B. Weiss: Influence of drugs on behavior controlled by internal and external stimuli J. Pharmacol. exp. Ther. 152, 388–396 (1966).
Mechner, F.: Probability relations within response sequences under ratio reinforcement. J. exp. Anal. Behav. 1, 109–121 (1958).
Sidman, M.: The temporal distribution of avoidance responses. J. comp. physiol. Psychol. 47, 399–402 (1954).
Stone, C. G.: Effects of some centrally acting drugs upon learning of escape and avoidance habits. J. comp. physiol. Psychol. 53, 33–37 (1960).
Terrace, H. S.: Discrimination learning with and without “errors”. J. exp. Anal. Behav. 6, 1–27 (1963).
Weiskrantz, L., and M. Mishkin: Effects of temporal and frontal cortical lesions on auditory discrimination in the monkey. Brain 81, 406–414 (1958).
Winer, B. J.: Statistical Principles in Experimental Design. New York: McGraw 1962.
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In conducting the research reported herein, the investigators adhered to the “Principles of Laboratory Animal Care” as established by the National Society for Medical Research.
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Wagman, W.D., Maxey, G.C. The effects of scopolamine hydrobromide and methyl scopolamine hydrobromide upon the discrimination of interoceptive and exteroceptive stimuli. Psychopharmacologia 15, 280–288 (1969). https://doi.org/10.1007/BF00401682
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DOI: https://doi.org/10.1007/BF00401682